{"title":"Cover Image","authors":"","doi":"10.1002/iub.2752","DOIUrl":null,"url":null,"abstract":"<p><b>On the Cover:</b> Imperative role of ROS during malignant transformation. ROS scavengers such as NRF2 and NADPH (PPP) exhibit cytostatic effects in normal cells. Loss of p53 and oncogenes elicits higher ROS production, leading to a cytotoxic effect. During angiogenesis, a higher ROS level sustains cell survival by affecting the NADPH, AMPK, and NRF2. In contrast, ROS generators such as hypoxia and low glucose levels lead to cell death at a minimal ROS generation. At the stage of invasion and metastasis, a higher ROS level facilitates cell survival via the downregulation of IDH1 and NADPH. The lower ROS generation via hypoxia and low matrix attachment facilitates cell death by Panda et al.; Article first published: 10 Apr 2024; https://doi.org/10.1002/iub.2821.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":14728,"journal":{"name":"IUBMB Life","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iub.2752","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IUBMB Life","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iub.2752","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
On the Cover: Imperative role of ROS during malignant transformation. ROS scavengers such as NRF2 and NADPH (PPP) exhibit cytostatic effects in normal cells. Loss of p53 and oncogenes elicits higher ROS production, leading to a cytotoxic effect. During angiogenesis, a higher ROS level sustains cell survival by affecting the NADPH, AMPK, and NRF2. In contrast, ROS generators such as hypoxia and low glucose levels lead to cell death at a minimal ROS generation. At the stage of invasion and metastasis, a higher ROS level facilitates cell survival via the downregulation of IDH1 and NADPH. The lower ROS generation via hypoxia and low matrix attachment facilitates cell death by Panda et al.; Article first published: 10 Apr 2024; https://doi.org/10.1002/iub.2821.
期刊介绍：
IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
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