Improved, Efficient, and Simple Methodology for the Resolution of Racemic Benoxaprofen: A Nonsteroidal Anti-Inflammatory Drug (NSAID)

IF 2.8 4区化学 Q2 CHEMISTRY, ANALYTICAL

Chirality Pub Date : 2024-08-28 DOI:10.1002/chir.23713

Siva Rama Kasibabu Velugula, Veera Babu Kagita, Ramadas Chavakula, Paul Douglas Sanasi

引用次数: 0

Abstract

The present article discloses an improved, efficient, and simple resolution methodology for the preparation of (S)-benoxaprofen which is a nonsteroidal anti-inflammatory drug (NSAID). The resolution of racemic benoxaprofen uses an easily available, efficient, recoverable, and cost-effective chiral reagent, namely, (1R,2S)-(+)-cis-1-amino-2-indanol. This novel resolution process is having a very high purity of (S)-benoxaprofen, greater than 99%, substantially free from (R)-benoxaprofen (less than 1%).

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改进、高效、简单的外消旋苯氧洛芬（一种非甾体抗炎药 (NSAID) ）解析方法

本文公开了一种用于制备非甾体抗炎药（NSAID）(S)-苯氧洛芬的改进、高效和简单的解析方法。外消旋苯氧洛芬的解析使用了一种易于获得、高效、可回收且成本低廉的手性试剂，即 (1R,2S)-(+)-顺式-1-氨基-2-茚满醇。这种新颖的解析工艺可获得纯度非常高的(S)-苯氧洛芬，其纯度大于 99%，而且基本上不含(R)-苯氧洛芬（小于 1%）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chirality 医学-分析化学

CiteScore

4.40

自引率

5.00%

发文量

124

审稿时长

1 months

期刊介绍： The main aim of the journal is to publish original contributions of scientific work on the role of chirality in chemistry and biochemistry in respect to biological, chemical, materials, pharmacological, spectroscopic and physical properties. Papers on the chemistry (physiochemical, preparative synthetic, and analytical), physics, pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.