Design, classification, and adverse effects of NSAIDs: A review on recent advancements

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2024-08-30 DOI:10.1016/j.bmc.2024.117899

Minhajul Arfeen , Ashish Srivastava , Noopur Srivastava , Riaz A. Khan , Suliman A. Almahmoud , Hamdoon A. Mohammed

{"title":"Design, classification, and adverse effects of NSAIDs: A review on recent advancements","authors":"Minhajul Arfeen , Ashish Srivastava , Noopur Srivastava , Riaz A. Khan , Suliman A. Almahmoud , Hamdoon A. Mohammed","doi":"10.1016/j.bmc.2024.117899","DOIUrl":null,"url":null,"abstract":"<div><p>Inflammation is a hallmark of many diseases, including cancer, neurodegenerative diseases like Alzheimer’s, type II diabetes, rheumatoid arthritis, and asthma. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been a cornerstone in the management of various inflammatory, pain, and fever-related conditions. As a result, NSAIDs have found their applications in new therapeutic areas. NSAIDs are known to act by inhibiting the cyclooxygenase (COX) pathway. In recent years, new strategies have been proposed to counter inflammation and develop safer COX inhibitors. This review discusses the design of new COX inhibitors, the derivatization of conventional NSAIDs, and their biological applications. The review also presents an integrated classification of NSAIDs incorporating both traditional chemical-based and function-based approaches, including a brief overview of the NSAIDs of natural origins. Additionally, the review addresses adverse effects associated with different NSAIDs, including effects associated with cardiovascular, renal, and hepatic complications emphasizing the need for the development of new and safer COX inhibitors.</p></div>","PeriodicalId":255,"journal":{"name":"Bioorganic & Medicinal Chemistry","volume":"112 ","pages":"Article 117899"},"PeriodicalIF":3.3000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioorganic & Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0968089624003134","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Inflammation is a hallmark of many diseases, including cancer, neurodegenerative diseases like Alzheimer’s, type II diabetes, rheumatoid arthritis, and asthma. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been a cornerstone in the management of various inflammatory, pain, and fever-related conditions. As a result, NSAIDs have found their applications in new therapeutic areas. NSAIDs are known to act by inhibiting the cyclooxygenase (COX) pathway. In recent years, new strategies have been proposed to counter inflammation and develop safer COX inhibitors. This review discusses the design of new COX inhibitors, the derivatization of conventional NSAIDs, and their biological applications. The review also presents an integrated classification of NSAIDs incorporating both traditional chemical-based and function-based approaches, including a brief overview of the NSAIDs of natural origins. Additionally, the review addresses adverse effects associated with different NSAIDs, including effects associated with cardiovascular, renal, and hepatic complications emphasizing the need for the development of new and safer COX inhibitors.

Abstract Image

查看原文本刊更多论文

非甾体抗炎药的设计、分类和不良反应：最新进展综述

炎症是许多疾病的标志，包括癌症、神经退行性疾病（如阿尔茨海默氏症）、II 型糖尿病、类风湿性关节炎和哮喘。非甾体抗炎药（NSAIDs）一直是治疗各种炎症、疼痛和发烧相关疾病的基石。因此，非甾体抗炎药已被应用于新的治疗领域。众所周知，非甾体抗炎药通过抑制环氧化酶（COX）途径发挥作用。近年来，人们提出了对抗炎症和开发更安全的 COX 抑制剂的新策略。本综述讨论了新型 COX 抑制剂的设计、传统非甾体抗炎药的衍生化及其生物学应用。综述还结合传统的化学方法和功能方法对非甾体抗炎药进行了综合分类，包括对天然非甾体抗炎药的简要概述。此外，该综述还讨论了与不同非甾体抗炎药相关的不良反应，包括与心血管、肾脏和肝脏并发症相关的影响，强调了开发更安全的新型 COX 抑制剂的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.