Recent advances in serum response factor posttranslational modifications and their therapeutic potential in cardiovascular and neurological diseases

IF 3.5 3区医学 Q2 PHARMACOLOGY & PHARMACY

Vascular pharmacology Pub Date : 2024-09-01 DOI:10.1016/j.vph.2024.107421

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Abstract

Serum Response Factor (SRF) is a key regulatory transcription factor present in various cell types throughout the body, playing essential roles in cellular functions under physiological conditions. Mutations and abnormal expression of SRF have been linked to the development of various diseases and disorders. Recent evidence highlights that post-translational modifications (PTMs) are critical for regulating SRF function in different cell types and contribute to disease pathogenesis. Targeting SRF-related PTMs is emerging as a promising therapeutic approach for treating SRF-associated diseases. In this review, we summarize recent advances in understanding SRF PTMs and their underlying regulatory mechanisms. We also explore the implications of SRF-PTM in related cardiovascular and neurological diseases and their potential for therapeutic intervention. This information underscores the significance of SRF PTMs in both physiological and pathological contexts, enhancing our understanding of disease mechanisms and paving the way for the development of novel therapeutic strategies.

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血清反应因子翻译后修饰的最新进展及其在心血管和神经疾病中的治疗潜力

血清反应因子（SRF）是一种关键的调控转录因子，存在于全身各种细胞类型中，在生理条件下对细胞功能起着至关重要的作用。SRF 的突变和异常表达与各种疾病和失调的发生有关。最近的证据表明，翻译后修饰（PTMs）是调节SRF在不同细胞类型中功能的关键，也是导致疾病发生的原因之一。靶向 SRF 相关的 PTMs 正在成为治疗 SRF 相关疾病的一种有前景的治疗方法。在这篇综述中，我们总结了了解 SRF PTMs 及其潜在调控机制的最新进展。我们还探讨了 SRF-PTM 在相关心血管和神经疾病中的影响及其治疗干预的潜力。这些信息强调了 SRF PTM 在生理和病理环境中的重要性，加深了我们对疾病机理的理解，并为开发新型治疗策略铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vascular pharmacology 医学-药学

CiteScore

6.60

自引率

2.50%

发文量

153

审稿时长

31 days

期刊介绍： Vascular Pharmacology publishes papers, which contains results of all aspects of biology and pharmacology of the vascular system. Papers are encouraged in basic, translational and clinical aspects of Vascular Biology and Pharmacology, utilizing approaches ranging from molecular biology to integrative physiology. All papers are in English. The Journal publishes review articles which include vascular aspects of thrombosis, inflammation, cell signalling, atherosclerosis, and lipid metabolism.