Role of Doppler Trasonography in Predicting Recovery From Early Allograft Dysfunction in Liver Postoperative Patients

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2024-09-01 DOI:10.1016/j.transproceed.2024.08.008

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引用次数: 0

Abstract

Objective

The aim of this study was to observe the recovery of liver function in patients with early allograft dysfunction (EAD) at one month postoperatively and explore whether early postoperative ultrasonic hemodynamic parameters can predict this outcome.

Methods

Patients with EAD postoperatively, who underwent orthotopic liver transplantation (OLT) in our hospital from December 2012 to June 2021, were retrospectively collected. Based on the recovery of liver function within one month, patients were divided into two groups: the recovery group (FR-1M) and the non-recovery group (Non-FR-1M). Ultrasonic hemodynamic parameters within the first seven days postoperatively were compared between the two groups.

Results

Among the 254 EAD patients included in this study, 158 (62%) patients recovered their liver function within one month. Of the 96 (38%) patients who did not recover, The RI of the non-FR-1M group was significantly lower than that of the FR-1M group on postoperative day 6 (POD6) and POD7. In the high resistance interval (RI all > 0.7), Group FR-1M represents a significant proportion (29/3, ratio 12/1), while in the low resistance interval (RI < 0.5 at least once), Group non-FR-1M accounts for a relatively high proportion (12/27, ratio 5/11). In the middle resistance interval (more than 1 time ≤ 0.7 and all ≥ 0.5), the proportions of the two groups are balanced (85/88, ratio 1/1).

Conclusion

Liver function typically recovers within 1 month in most patients with EAD. The high resistance state of the hepatic artery in the early postoperative period is illustrative an important role in its recovery. Low-resistance state is most unfavorable for the recovery of liver function.

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多普勒超声在预测肝脏术后患者早期移植物功能障碍恢复中的作用

目的：本研究旨在观察早期同种异体肝移植功能障碍（EAD）患者术后一个月的肝功能恢复情况，并探讨术后早期超声血流动力学参数能否预测这一结果：方法：回顾性收集2012年12月至2021年6月在我院接受正位肝移植（OLT）的术后EAD患者。根据患者一个月内的肝功能恢复情况，将其分为两组：恢复组（FR-1M）和非恢复组（Non-FR-1M）。比较两组患者术后前七天的超声血流动力学参数：在 254 名 EAD 患者中，有 158 名（62%）患者在一个月内恢复了肝功能。术后第 6 天（POD6）和第 7 天，非 FR-1M 组的 RI 明显低于 FR-1M 组。在高阻力区间（RI 均大于 0.7），FR-1M 组占相当大的比例（29/3，比率为 12/1），而在低阻力区间（RI 至少一次小于 0.5），非 FR-1M 组所占比例相对较高（12/27，比率为 5/11）。在中阻力区间（超过 1 次≤0.7 且全部≥0.5），两组比例均衡（85/88，比率 1/1）：结论：大多数 EAD 患者的肝功能通常在 1 个月内恢复。结论：大多数 EAD 患者的肝功能通常会在 1 个月内恢复，术后早期肝动脉的高阻力状态对肝功能恢复起着重要作用。低阻力状态最不利于肝功能的恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.