Infection prevention and control in cystic fibrosis: An update of a systematic review of interventions

IF 5.4 2区医学 Q1 RESPIRATORY SYSTEM

Journal of Cystic Fibrosis Pub Date : 2025-03-01 DOI:10.1016/j.jcf.2024.08.004

Nicola J Rowbotham , Sherie Smith , Nikki Jahnke , Sarah Milczanowski , Zoe C Elliott , Andrew P Prayle , Alan R Smyth

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引用次数: 0

Abstract

Preventing transmissible infection is a priority in cystic fibrosis (CF) care. This is an update of a systematic review of the evidence for infection prevention and control interventions in CF.

Our full protocol can be found on PROSPERO (CRD42018109999). We searched for studies and guidelines which included interventions for infection prevention and control in CF.

We included 39 studies and 7 guidelines. Strategies included: cohort or individual segregation, hand hygiene, facemasks, equipment, enhanced adherence or a combination of these. Many studies showed a reduction in transmission with segregation. However, the certainty of evidence (using GRADE) was low or very low. Most guideline recommendations have little evidence to support them, with no updates since our original review.

Undertaking RCTs in this area is ethically difficult. Large-scale registry-based studies may be the best pragmatic approach. Benefits of infection control must be balanced against the intrusion in the lives of people with CF.

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囊性纤维化的感染预防和控制：干预措施系统回顾的更新。

预防传染性感染是囊性纤维化（CF）护理的首要任务。本文是对CF感染预防和控制干预措施证据的系统性综述的更新。我们的完整方案可在 PROSPERO (CRD42018109999) 上找到。我们检索了包含CF感染预防和控制干预措施的研究和指南。我们纳入了 39 项研究和 7 份指南。干预策略包括：群体或个体隔离、手部卫生、口罩、设备、加强依从性或这些策略的组合。许多研究表明，隔离可减少传播。然而，证据的确定性（采用 GRADE）较低或很低。大多数指南建议几乎没有证据支持，自我们最初审查以来也没有更新。在这一领域开展 RCT 研究在伦理上是困难的。基于登记册的大规模研究可能是最好的实用方法。感染控制的益处必须与对 CF 患者生活的干扰相平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cystic Fibrosis 医学-呼吸系统

CiteScore

10.10

自引率

13.50%

发文量

1361

审稿时长

50 days

期刊介绍： The Journal of Cystic Fibrosis is the official journal of the European Cystic Fibrosis Society. The journal is devoted to promoting the research and treatment of cystic fibrosis. To this end the journal publishes original scientific articles, editorials, case reports, short communications and other information relevant to cystic fibrosis. The journal also publishes news and articles concerning the activities and policies of the ECFS as well as those of other societies related the ECFS.