Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Antioxidants Pub Date : 2024-08-14 DOI:10.3390/antiox13080983

Colin J Gimblet, Nicholas T Kruse, Katharine Geasland, Jeni Michelson, Mingyao Sun, Patrick Ten Eyck, Cari Linkenmeyer, Safur Rehman Mandukhail, Matthew J Rossman, Meenakshi Sambharia, Michel Chonchol, Manjula Kurella Tamura, Douglas Seals, Karin F Hoth, Diana Jalal

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引用次数: 0

Abstract

Chronic kidney disease (CKD) increases the risk of cardiovascular disease and cognitive impairment. Curcumin is a polyphenol that improves vascular and cognitive function in older adults; however, its effects on vascular and cognitive function in patients with CKD are unknown. We hypothesized that curcumin supplementation would improve vascular and cognitive function in patients with CKD. Eighty-eight adults diagnosed with stage 3b or 4 CKD (aged 66 ± 8 years, 75% male) participated in a 12-month, randomized, double-blind, placebo-controlled study to test the effects of curcumin (Longvida^®, 2000 mg/day) on vascular and cognitive function. Our primary outcome was brachial artery flow-mediated dilation (FMD). Our secondary outcomes were nitroglycerin-mediated dilation, carotid-femoral pulse wave velocity (cfPWV), and cognitive function assessed via the NIH Toolbox Cognition Battery. At baseline, the mean estimated glomerular filtration rate was 34.7 ± 10.8, and the median albumin/creatinine ratio was 81.9 (9.7, 417.3). A total of 44% of participants had diabetes. Compared with placebo, 12 months of curcumin did not improve FMD (median change from baseline was -0.7 (-2.1, 1.1) and -0.1 (-1.5, 1.5) for curcumin and placebo, respectively, with p = 0.69). Similarly, there were no changes in nitroglycerin-mediated dilation, cfPWV, or cognitive outcomes. These results do not support chronic curcumin supplementation to improve vascular and cognitive function in patients with CKD.

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姜黄素补充剂与慢性肾病患者的血管和认知功能：随机对照试验

慢性肾脏病（CKD）会增加罹患心血管疾病和认知障碍的风险。姜黄素是一种能改善老年人血管和认知功能的多酚类物质，但它对慢性肾脏病患者血管和认知功能的影响尚不清楚。我们假设姜黄素补充剂能改善慢性肾脏病患者的血管和认知功能。88 名被诊断为 3b 期或 4 期慢性肾脏病的成年人（66 ± 8 岁，75% 为男性）参加了一项为期 12 个月的随机、双盲、安慰剂对照研究，以测试姜黄素（龙维达®，2000 毫克/天）对血管和认知功能的影响。我们的主要结果是肱动脉血流介导的扩张（FMD）。我们的次要结果是硝酸甘油介导的扩张、颈动脉-股动脉脉搏波速度（cfPWV）以及通过美国国立卫生研究院工具箱认知测试评估的认知功能。基线时，估计肾小球滤过率的平均值为 34.7 ± 10.8，白蛋白/肌酐比值的中位数为 81.9 (9.7, 417.3)。共有 44% 的参与者患有糖尿病。与安慰剂相比，服用姜黄素 12 个月并未改善 FMD（姜黄素和安慰剂与基线相比的中位变化分别为-0.7（-2.1，1.1）和-0.1（-1.5，1.5），P = 0.69）。同样，硝酸甘油介导的扩张、cfPWV 或认知结果也没有变化。这些结果不支持长期补充姜黄素来改善慢性肾脏病患者的血管和认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.