{"title":"1029 – ETIOLOGY, PATHOGENESIS AND CELL-OF-ORIGIN OF MLL-REARRANGED INFANT/PEDIATRIC B-CELL ALL","authors":"Pablo Menendez","doi":"10.1016/j.exphem.2024.104330","DOIUrl":null,"url":null,"abstract":"<div><p>Pediatric acute leukemia is clinically and biologically differentiated from adult acute leukemia. The latter is a disease associated with aging while in childhood leukemia is associated with growth and development. In fact, pediatric leukemia is considered and studied as a developmental disease. In this session, I will present the advances that our laboratory has made in recent years in the biology and clinical picture of pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially that associated with rearrangements in the KTM2A (MLL) gene. I will discuss aspects of the cell of origin and the leukemia-initiating cell as well as other cellular, molecular and genetic aspects that underlie the etiology and pathogenesis of these pediatric/childhood leukemias. Finally, I will share recently discovered therapeutic aspects to circumvent glucocorticoid resistance.</p></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"137 ","pages":"Article 104330"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301472X24001899/pdfft?md5=0b0e98392745c8ea49bc1f9846a6a934&pid=1-s2.0-S0301472X24001899-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental hematology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301472X24001899","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Pediatric acute leukemia is clinically and biologically differentiated from adult acute leukemia. The latter is a disease associated with aging while in childhood leukemia is associated with growth and development. In fact, pediatric leukemia is considered and studied as a developmental disease. In this session, I will present the advances that our laboratory has made in recent years in the biology and clinical picture of pediatric B-cell acute lymphoblastic leukemia (B-ALL), especially that associated with rearrangements in the KTM2A (MLL) gene. I will discuss aspects of the cell of origin and the leukemia-initiating cell as well as other cellular, molecular and genetic aspects that underlie the etiology and pathogenesis of these pediatric/childhood leukemias. Finally, I will share recently discovered therapeutic aspects to circumvent glucocorticoid resistance.
期刊介绍：
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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