{"title":"3019 – ROLE OF MEAN PLATELET VOLUME (MPV) AS A PREDICTIVE BIOMARKER IN DIABETES MELLITUS TYPE 2","authors":"Christabel Anyika , Victory Oparaocha , Suma Alluri , Mahathi Thotakura , Ashok Chakravarthy","doi":"10.1016/j.exphem.2024.104341","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Mean platelet volume (MPV) is an efficient, easily available, and cost-effective marker, which can be used in monitoring glycaemic status in Type 2 Diabetes Mellitus patients. Platelet volume indices (PVI) such as MPV are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications.</p></div><div><h3>Methods & Results</h3><p>Sixty four patients were included to study the link, between blood sugar levels and MPV in conjunction with glycated hemoglobin (HbA1c), in both men and women. Men were notably older with an age of 58.4 years compared to women who had an average age of 50.6 years. Men had a higher MPV of 9.2 fl compared to women 8.4 fl indicating differences in platelet characteristics based on gender within the diabetic population. Additionally, men had HbA1c levels at 8.4% compared to women at 7.9%, which suggests variations in blood sugar control between the genders. Similarly, men showed blood sugar levels at 194.7 mg/dL compared to women's 180 mg/dL. These results highlight the importance of considering gender factors in managing diabetes and stress the need for approaches to enhance patient care and outcomes.</p></div><div><h3>Conclusion</h3><p>Understanding the relationship between diabetes and thrombosis is crucial for assessing risks and devising management plans. Our research emphasizes the importance of Mean Platelet Volume (MPV) as a marker for evaluating the likelihood of blood clots in individuals, particularly concerning blood sugar control. By acknowledging the significance of MPV in foreseeing clotting events, healthcare providers can improve their ability to pinpoint individuals at risk and tailor treatments accordingly, ultimately enhancing outcomes in diabetes care. Further exploration of MPVs usefulness as a tool in blood clotting issues is necessary to fully exploit its clinical benefits.</p></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"137 ","pages":"Article 104341"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301472X24002005/pdfft?md5=c3f3ed03fb68952b8ebebda708b650da&pid=1-s2.0-S0301472X24002005-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental hematology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301472X24002005","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
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Abstract
Background
Mean platelet volume (MPV) is an efficient, easily available, and cost-effective marker, which can be used in monitoring glycaemic status in Type 2 Diabetes Mellitus patients. Platelet volume indices (PVI) such as MPV are the indicators of increased platelet activity and can be considered as potential biomarkers for diabetic complications.
Methods & Results
Sixty four patients were included to study the link, between blood sugar levels and MPV in conjunction with glycated hemoglobin (HbA1c), in both men and women. Men were notably older with an age of 58.4 years compared to women who had an average age of 50.6 years. Men had a higher MPV of 9.2 fl compared to women 8.4 fl indicating differences in platelet characteristics based on gender within the diabetic population. Additionally, men had HbA1c levels at 8.4% compared to women at 7.9%, which suggests variations in blood sugar control between the genders. Similarly, men showed blood sugar levels at 194.7 mg/dL compared to women's 180 mg/dL. These results highlight the importance of considering gender factors in managing diabetes and stress the need for approaches to enhance patient care and outcomes.
Conclusion
Understanding the relationship between diabetes and thrombosis is crucial for assessing risks and devising management plans. Our research emphasizes the importance of Mean Platelet Volume (MPV) as a marker for evaluating the likelihood of blood clots in individuals, particularly concerning blood sugar control. By acknowledging the significance of MPV in foreseeing clotting events, healthcare providers can improve their ability to pinpoint individuals at risk and tailor treatments accordingly, ultimately enhancing outcomes in diabetes care. Further exploration of MPVs usefulness as a tool in blood clotting issues is necessary to fully exploit its clinical benefits.
期刊介绍：
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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