{"title":"3014 – MEAN PLATELET VOLUME - A NOVEL BIOMARKER IN VARIOUS CARDIOVASCULAR DISEASES","authors":"Lovett Igburuke , Vasu Alluri , Suma Alluri , Shreya Rekhi , Rajesh Goud , Sarat Chandra","doi":"10.1016/j.exphem.2024.104336","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Cardiac diseases pose a global health challenge, necessitating the identification of biomarkers for early detection and management. Inflammation plays a role in many cardiac diseases, highlighting the need for inflammatory markers. Mean platelet volume (MPV), is a promising inflammatory biomarker in cardiac diseases.</p></div><div><h3>Methods</h3><p>Complete Blood Count reports were collected and observed in treatment-naive patients from January 2021 to January 2023, particularly in those having cardiac diseases (Myocardial infarction {MI}, Pericarditis, Myocarditis, and Atrial fibrillation {Afib}), respective changes in MPV counts were observed and tallied. This prospective study investigated the correlation of MPV with various cardiac diseases, considering the age and sex disparities.</p></div><div><h3>Results</h3><p>The study comprised 87 inpatients with cardiac diseases, the patients with MPV values exceeding 11 fl are as shown on the graph. The incidence of MPV more than 11fl in the present study is as follows: 50% of AFib exhibited the highest MPV 12.1fl (male 75 yrs). 18.8% of Myocarditis had the highest MPV of 11.3fl in both genders, (average 21.5 yrs). 11.9% of Pericarditis showed the highest MPV 11.9 fl (female 18yrs) 12.4% MI recorded the highest MPV of 11.9 fl in both genders (average 47.5 years).</p></div><div><h3>Conclusion</h3><p>Based on our evidence and the strong association of platelets in the pathophysiology of cardiac diseases we conclude MPV has significance in the following order Afib, Myocarditis, Pericarditis, and MI. Age, sex, and menopausal status also influence the MPV dynamics. Integrating MPV into clinical practice facilitates personalized preventive strategies and risk stratification.</p></div>","PeriodicalId":12202,"journal":{"name":"Experimental hematology","volume":"137 ","pages":"Article 104336"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301472X24001954/pdfft?md5=bd1a02592254ae27177d541dec130183&pid=1-s2.0-S0301472X24001954-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental hematology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0301472X24001954","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
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Abstract
Background
Cardiac diseases pose a global health challenge, necessitating the identification of biomarkers for early detection and management. Inflammation plays a role in many cardiac diseases, highlighting the need for inflammatory markers. Mean platelet volume (MPV), is a promising inflammatory biomarker in cardiac diseases.
Methods
Complete Blood Count reports were collected and observed in treatment-naive patients from January 2021 to January 2023, particularly in those having cardiac diseases (Myocardial infarction {MI}, Pericarditis, Myocarditis, and Atrial fibrillation {Afib}), respective changes in MPV counts were observed and tallied. This prospective study investigated the correlation of MPV with various cardiac diseases, considering the age and sex disparities.
Results
The study comprised 87 inpatients with cardiac diseases, the patients with MPV values exceeding 11 fl are as shown on the graph. The incidence of MPV more than 11fl in the present study is as follows: 50% of AFib exhibited the highest MPV 12.1fl (male 75 yrs). 18.8% of Myocarditis had the highest MPV of 11.3fl in both genders, (average 21.5 yrs). 11.9% of Pericarditis showed the highest MPV 11.9 fl (female 18yrs) 12.4% MI recorded the highest MPV of 11.9 fl in both genders (average 47.5 years).
Conclusion
Based on our evidence and the strong association of platelets in the pathophysiology of cardiac diseases we conclude MPV has significance in the following order Afib, Myocarditis, Pericarditis, and MI. Age, sex, and menopausal status also influence the MPV dynamics. Integrating MPV into clinical practice facilitates personalized preventive strategies and risk stratification.
期刊介绍：
Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
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