Recent advances in the 3D skin bioprinting for regenerative medicine: Cells, biomaterials, and methods.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI:10.1177/08853282241276799

Loyna Nobile Carvalho, Lucas Correia Peres, Vivian Alonso-Goulart, Beatriz Jardim Dos Santos, Mário Fernando Alves Braga, Felipe Dos Anjos Rodrigues Campos, Gabriela de Aquino Pinto Palis, Ludmilla Sousa Quirino, Laura Duarte Guimarães, Sofia Alencar Lafetá, Márcia Mayumi Omi Simbara, Letícia de Souza Castro-Filice

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引用次数: 0

Abstract

The skin is a tissue constantly exposed to the risk of damage, such as cuts, burns, and genetic disorders. The standard treatment is autograft, but it can cause pain to the patient being extremely complex in patients suffering from burns on large body surfaces. Considering that there is a need to develop technologies for the repair of skin tissue like 3D bioprinting. Skin is a tissue that is approximately 1/16 of the total body weight and has three main layers: epidermis, dermis, and hypodermis. Therefore, there are several studies using cells, biomaterials, and bioprinting for skin regeneration. Here, we provide an overview of the structure and function of the epidermis, dermis, and hypodermis, and showed in the recent research in skin regeneration, the main cells used, biomaterials studied that provide initial support for these cells, allowing the growth and formation of the neotissue and general characteristics, advantages and disadvantages of each methodology and the landmarks in recent research in the 3D skin bioprinting.

查看原文本刊更多论文

用于再生医学的三维皮肤生物打印技术的最新进展：细胞、生物材料和方法。

皮肤是一种经常面临损伤风险的组织，如割伤、烧伤和遗传性疾病。标准的治疗方法是自体移植，但这种方法会给患者带来痛苦，而且对于体表大面积烧伤的患者来说极其复杂。有鉴于此，有必要开发皮肤组织修复技术，如三维生物打印技术。皮肤是一种组织，约占人体总重量的 1/16，主要有三层：表皮、真皮和皮下组织。因此，有多项研究利用细胞、生物材料和生物打印技术来促进皮肤再生。在此，我们将概述表皮、真皮和真皮下层的结构和功能，并展示最近的皮肤再生研究、使用的主要细胞、为这些细胞提供初始支持的生物材料研究，以及允许新组织生长和形成的一般特征、每种方法的优缺点和最近三维皮肤生物打印研究的标志性成果。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.