Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour

IF 3.9 2区 医学 Q1 PSYCHIATRY
Jerome C. Foo , Maja P. Völker , Fabian Streit , Josef Frank , Norman Zacharias , Lea Zillich , Lea Sirignano , Peter Nürnberg , Thomas F. Wienker , Michael Wagner , Markus M. Nöthen , Michael Nothnagel , Henrik Walter , Bernd Lenz , Rainer Spanagel , Falk Kiefer , Georg Winterer , Marcella Rietschel , Stephanie H. Witt
{"title":"Polygenic risk scores for nicotine use and family history of smoking are associated with smoking behaviour","authors":"Jerome C. Foo ,&nbsp;Maja P. Völker ,&nbsp;Fabian Streit ,&nbsp;Josef Frank ,&nbsp;Norman Zacharias ,&nbsp;Lea Zillich ,&nbsp;Lea Sirignano ,&nbsp;Peter Nürnberg ,&nbsp;Thomas F. Wienker ,&nbsp;Michael Wagner ,&nbsp;Markus M. Nöthen ,&nbsp;Michael Nothnagel ,&nbsp;Henrik Walter ,&nbsp;Bernd Lenz ,&nbsp;Rainer Spanagel ,&nbsp;Falk Kiefer ,&nbsp;Georg Winterer ,&nbsp;Marcella Rietschel ,&nbsp;Stephanie H. Witt","doi":"10.1016/j.drugalcdep.2024.112415","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Formal genetics studies show that smoking is influenced by genetic factors; exploring this on the molecular level can offer deeper insight into the etiology of smoking behaviours.</p></div><div><h3>Methods</h3><p>Summary statistics from the latest wave of the GWAS and Sequencing Consortium of Alcohol and Nicotine (GSCAN) were used to calculate polygenic risk scores (PRS) in a sample of ~2200 individuals who smoke/individuals who never smoked. The associations of smoking status with PRS for Smoking Initiation (i.e., Lifetime Smoking; SI-PRS), and Fagerström Test for Nicotine Dependence (FTND) score with PRS for Cigarettes per Day (CpD-PRS) were examined, as were distinct/additive effects of parental smoking on smoking status.</p></div><div><h3>Results</h3><p>SI-PRS explained 10.56% of variance (Nagelkerke-R<sup>2</sup>) in smoking status (p=6.45x10<sup><em>−</em>30</sup>). In individuals who smoke, CpD-PRS was associated with FTND score (R<sup>2</sup>=5.03%, p=1.88x10<sup><em>–</em>12</sup>). Parental smoking alone explained R<sup>2</sup>=3.06% (p=2.43×10<sup>−12</sup>) of smoking status, and 0.96% when added to the most informative SI-PRS model (total R²=11.52%).</p></div><div><h3>Conclusion</h3><p>These results show the potential utility of molecular genetic data for research investigating smoking prevention. The fact that PRS explains more variance than family history highlights progress from formal to molecular genetics; the partial overlap and increased predictive value when using both suggests the importance of combining these approaches.</p></div>","PeriodicalId":11322,"journal":{"name":"Drug and alcohol dependence","volume":"263 ","pages":"Article 112415"},"PeriodicalIF":3.9000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0376871624013401/pdfft?md5=07785b4116088d737363aea286342ea5&pid=1-s2.0-S0376871624013401-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug and alcohol dependence","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0376871624013401","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction

Formal genetics studies show that smoking is influenced by genetic factors; exploring this on the molecular level can offer deeper insight into the etiology of smoking behaviours.

Methods

Summary statistics from the latest wave of the GWAS and Sequencing Consortium of Alcohol and Nicotine (GSCAN) were used to calculate polygenic risk scores (PRS) in a sample of ~2200 individuals who smoke/individuals who never smoked. The associations of smoking status with PRS for Smoking Initiation (i.e., Lifetime Smoking; SI-PRS), and Fagerström Test for Nicotine Dependence (FTND) score with PRS for Cigarettes per Day (CpD-PRS) were examined, as were distinct/additive effects of parental smoking on smoking status.

Results

SI-PRS explained 10.56% of variance (Nagelkerke-R2) in smoking status (p=6.45x1030). In individuals who smoke, CpD-PRS was associated with FTND score (R2=5.03%, p=1.88x1012). Parental smoking alone explained R2=3.06% (p=2.43×10−12) of smoking status, and 0.96% when added to the most informative SI-PRS model (total R²=11.52%).

Conclusion

These results show the potential utility of molecular genetic data for research investigating smoking prevention. The fact that PRS explains more variance than family history highlights progress from formal to molecular genetics; the partial overlap and increased predictive value when using both suggests the importance of combining these approaches.

尼古丁使用的多基因风险评分和吸烟家族史与吸烟行为有关
方法利用酒精和尼古丁全球基因组研究和测序联合会(GSCAN)最新一期的汇总统计数据,计算了约2200名吸烟者/从不吸烟者样本的多基因风险得分(PRS)。结果SI-PRS解释了吸烟状况10.56%的方差(Nagelkerke-R2)(p=6.45x10-30)。在吸烟者中,CpD-PRS 与 FTND 评分相关(R2=5.03%,p=1.88x10-12)。父母吸烟本身对吸烟状况的解释率为 R2=3.06%(p=2.43×10-12),如果加入信息量最大的 SI-PRS 模型,则解释率为 0.96%(总 R²=11.52%)。PRS比家族史能解释更多的变异,这一事实凸显了从形式遗传学到分子遗传学的进步;两者的部分重叠和预测价值的提高表明了将这些方法结合起来的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Drug and alcohol dependence
Drug and alcohol dependence 医学-精神病学
CiteScore
7.40
自引率
7.10%
发文量
409
审稿时长
41 days
期刊介绍: Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信