Facile construction of binary metal oxide heterojunction with hexagonal boron nitride nanohybrid electrocatalyst for the detection of flutamide

IF 5.5 3区工程技术 Q1 ENGINEERING, CHEMICAL

Journal of the Taiwan Institute of Chemical Engineers Pub Date : 2024-08-27 DOI:10.1016/j.jtice.2024.105706

Thangavelu Sakthi Priya , Tse-Wei Chen , Shen-Ming Chen , Thangavelu Kokulnathan , Faheem Ahmed , Afzal Hussain , Mohamed Fahad Alajmi

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引用次数: 0

Abstract

Background

Flutamide (FU) is a potential anti-androgen drug significantly prescribed to all human beings. The high solubility and poor degradability of its metabolites can adversely affect the balance of the ecosystem. Therefore, developing an efficient and reliable technique to detect this pollutant is essential. Consequently, electrochemical sensors have been widely used for the monitoring of various real-world samples.

Methods

Hence, nickel-zinc oxide (NZO) with hexagonal boron nitride (h-BN) nanocomposite was prepared as a proficient electrocatalyst in FU detection. Several spectroscopic measurements were carried out to characterize the prepared materials. Our NZO/h-BN nanocomposite was utilized to modify the glassy carbon electrode (GCE) and its relative catalytic activity was scrutinized with impedance and various voltammetric techniques.

Significant findings

Based on the results, our NZO/h-BN/GCE sensor exhibited high conductance, appreciable linear ranges, low detection limit (0.002 μM), optimal sensitivity (2.149 µA µM⁻¹ cm⁻²), and high selectivity with good repeatability, and reproducibility results. Furthermore, the practical utility of the sensor was studied by monitoring FU in human and environmental samples. Based on the outcomes, our NZO/h-BN/GCE is a promising electrochemical platform for the detection of FU.

Abstract Image

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轻松构建用于检测氟他胺的二元金属氧化物异质结与六方氮化硼纳米杂化电催化剂

背景氟他胺（FU）是一种潜在的抗雄激素药物，是人类的主要处方药。其代谢物溶解度高、降解性差，会对生态系统的平衡产生不利影响。因此，开发一种高效可靠的技术来检测这种污染物至关重要。因此，电化学传感器已被广泛用于监测现实世界中的各种样本。方法因此，制备了镍锌氧化物（NZO）与六方氮化硼（h-BN）纳米复合材料，作为检测 FU 的高效电催化剂。对制备的材料进行了多项光谱测量，以确定其特性。研究结果表明，我们的 NZO/h-BN/GCE 传感器具有高电导率、可观的线性范围、低检测限（0.002 μM）、最佳灵敏度（2.149 µA µM-1 cm-2）、高选择性、良好的重复性和再现性。此外，通过监测人体和环境样本中的 FU，研究了该传感器的实用性。根据研究结果，我们的 NZO/h-BN/GCE 是一种很有前景的 FU 检测电化学平台。

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来源期刊

Journal of the Taiwan Institute of Chemical Engineers 工程技术-工程：化工

CiteScore

9.10

自引率

14.00%

发文量

362

审稿时长

35 days

期刊介绍： Journal of the Taiwan Institute of Chemical Engineers (formerly known as Journal of the Chinese Institute of Chemical Engineers) publishes original works, from fundamental principles to practical applications, in the broad field of chemical engineering with special focus on three aspects: Chemical and Biomolecular Science and Technology, Energy and Environmental Science and Technology, and Materials Science and Technology. Authors should choose for their manuscript an appropriate aspect section and a few related classifications when submitting to the journal online.