Nebuhaler or nebulizer for high dose bronchodilator therapy in chronic bronchitis: a comparison

Martin B. Allen, Jenny Pugh, Robert S.E. Wilson
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引用次数: 9

Abstract

We have compared the clinical efficacy of high dose terbutaline sulphate (10 mg four times daily) delivered by either a Nebuhaler or jet nebulizer in 13 patients with chronic bronchitis in a 2-week, open, crossover study.

Both treatment regimens improved run-in symptom scores but no significant changes were recorded in peak flow and spirometry. Side-effects were more common with the Nebuhaler and more patients preferred the nebulizer. However, the Nebuhaler is an alternative therapeutic option for delivery of high doses of bronchodilators in patients with chronic bronchitis.

大剂量支气管扩张剂治疗慢性支气管炎的雾化雾化器与雾化雾化器的比较
在一项为期2周的开放交叉研究中,我们比较了高剂量特布他林硫酸盐(10mg,每日4次)由Nebuhaler或喷射雾化器给药13例慢性支气管炎患者的临床疗效。两种治疗方案均改善了磨合症状评分,但在峰值流量和肺活量方面没有显著变化。副作用更常见的Nebuhaler和更多的患者喜欢雾化器。然而,Nebuhaler是慢性支气管炎患者给予高剂量支气管扩张剂的另一种治疗选择。
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