{"title":"Single-Nanoparticle Electrochemical Collision for Monitoring Self-Assembly of Thiol Molecules on Au Nanoparticles.","authors":"Yiyan Bai","doi":"10.3390/bios14080393","DOIUrl":null,"url":null,"abstract":"<p><p>A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based method was developed to monitor the self-assembly processes of 6-mercapto-1-hexanol (6-MCH) and 1-hexanethiol (MCH) on Au NPs at the single-particle level, and to investigate the self-assembly kinetics exactly. Results showed that the self-assembly processes of both consisted of rapid adsorption and slow recombination. However, the adsorption rate of MCH was significantly lower than that of 6-MCH due to the poorer polarity. Also noteworthy is that the rapid adsorption of 6-MCH on Au NPs conformed to the Langmuir model of diffusion control. Hence, the proposed SNEC-based method could serve as a complementary method to research the self-assembly mechanism of functionalized NPs.</p>","PeriodicalId":48608,"journal":{"name":"Biosensors-Basel","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11353042/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors-Basel","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3390/bios14080393","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
A precise understanding of the self-assembly kinetics of small molecules on nanoparticles (NPs) can give greater control over the size and architecture of the functionalized NPs. Herein, a single-nanoparticle electrochemical collision (SNEC)-based method was developed to monitor the self-assembly processes of 6-mercapto-1-hexanol (6-MCH) and 1-hexanethiol (MCH) on Au NPs at the single-particle level, and to investigate the self-assembly kinetics exactly. Results showed that the self-assembly processes of both consisted of rapid adsorption and slow recombination. However, the adsorption rate of MCH was significantly lower than that of 6-MCH due to the poorer polarity. Also noteworthy is that the rapid adsorption of 6-MCH on Au NPs conformed to the Langmuir model of diffusion control. Hence, the proposed SNEC-based method could serve as a complementary method to research the self-assembly mechanism of functionalized NPs.
Biosensors-BaselBiochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍：
Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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