Obesity-associated Inflammation and Alloimmunity.

IF 5.3 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2025-04-01 Epub Date: 2024-08-28 DOI:10.1097/TP.0000000000005183

Hao Zhou, Merih Gizlenci, Yao Xiao, Friederike Martin, Keita Nakamori, Elizabeth M Zicari, Yuko Sato, Stefan G Tullius

引用次数: 0

Abstract

Obesity is a worldwide health problem with a rapidly rising incidence. In organ transplantation, increasing numbers of patients with obesity accumulate on waiting lists and undergo surgery. Obesity is in general conceptualized as a chronic inflammatory disease, potentially impacting alloimmune response and graft function. Here, we summarize our current understanding of cellular and molecular mechanisms that control obesity-associated adipose tissue inflammation and provide insights into mechanisms affecting transplant outcomes, emphasizing on the beneficial effects of weight loss on alloimmune responses.

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与肥胖相关的炎症和同种免疫。

肥胖症是一个世界性的健康问题，发病率迅速上升。在器官移植中，越来越多的肥胖症患者被列入等待名单并接受手术。肥胖一般被认为是一种慢性炎症性疾病，可能会影响同种免疫反应和移植功能。在此，我们总结了目前我们对控制肥胖相关脂肪组织炎症的细胞和分子机制的理解，并深入探讨了影响移植结果的机制，强调了减肥对同种免疫反应的有益影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.