Seroprevalence of Lyme Disease in Children With Facial Nerve Palsy.

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Child Neurology Pub Date : 2024-08-01 Epub Date: 2024-08-28 DOI:10.1177/08830738241272069

Bethany Murphy, Julissa Veras, Sindhura Kolli, Brielle Formanowski, Patricia Greenberg, Lawrence Kleinman, Amisha Malhotra, Vikram Bhise

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Abstract

This retrospective chart review examined children with documented Lyme disease serology in New Jersey aged <21 years presenting with facial nerve palsy. The presence of symptoms including tick bite, fever, headache, and arthritis was recorded. Data were categorized based on demographic factors, and multivariate regression was employed. We enrolled 122 children, 54% female (mean age of 11.4 ± 5.1 years); 22.1% had Lyme disease. Fever was a significant predictor of Lyme disease (P = .01), confirmed by multivariate regression (odds ratio [OR] = 16.11, 95% confidence interval [CI] = 2.04, 366.14), as was male gender (P = .01, OR = 3.68, 95% CI = 1.21, 12.89). This association held especially true in Lyme-endemic regions (prevalence ≥ 0.35). The combination of headache with fever was also significantly predictive (P = .01). We found no significant predictive value in the remaining symptoms. These findings suggest that clinical predictors may be useful in diagnosing Lyme disease and initiating early empiric treatment.

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莱姆病在面神经麻痹儿童中的血清流行率。

这项回顾性病历审查检查了新泽西州有莱姆病血清学记录的儿童（年龄 P = .01），多变量回归证实了这一点（几率比 [OR] = 16.11，95% 置信区间 [CI] = 2.04，366.14），男性性别也证实了这一点（P = .01，OR = 3.68，95% CI = 1.21，12.89）。这种关联在莱姆病流行地区尤为明显（发病率≥ 0.35）。头痛合并发烧也具有显著的预测价值（P = .01）。我们发现其余症状没有明显的预测价值。这些研究结果表明，临床预测因子可能有助于诊断莱姆病和开始早期经验性治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Child Neurology 医学-临床神经学

CiteScore

4.20

自引率

5.30%

发文量

111

审稿时长

3-6 weeks

期刊介绍： The Journal of Child Neurology (JCN) embraces peer-reviewed clinical and investigative studies from a wide-variety of neuroscience disciplines. Focusing on the needs of neurologic patients from birth to age 18 years, JCN covers topics ranging from assessment of new and changing therapies and procedures; diagnosis, evaluation, and management of neurologic, neuropsychiatric, and neurodevelopmental disorders; and pathophysiology of central nervous system diseases.