Anca Iuliana Pîslaru, Sabinne-Marie Albișteanu, Adina Carmen Ilie, Ramona Ștefaniu, Aurelia Mârza, Ștefan Moscaliuc, Mălina Nicoară, Ana-Maria Turcu, Gabriela Grigoraș, Ioana Dana Alexa
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引用次数: 0
Abstract
Age is but one significant prognostic factor in lung cancer, influencing survival, treatment response, and outcomes. This narrative review synthesizes findings from searches of 11 leading databases of research studies, systematic reviews, book chapters, and clinical trial reports on lung cancer in senior patients, with a focus on geriatric assessment as well as biomarkers. Key prognostic factors for lung cancer in seniors include biological age, functional capability, physical and psychological comorbidities, frailty, nutrition, status, and biomarkers like DNA methylation age. We identified the most valuable assessments that balance efficacy with quality of life. Optimizing care and improving outcomes with senior lung cancer patients benefits from a tailored therapeutic approach incorporating a complex geriatric assessment. A multidisciplinary collaboration between geriatricians, oncologists, and pulmonologists is crucial.
年龄只是肺癌预后的一个重要因素，它影响着患者的生存、治疗反应和预后。本叙述性综述综合了从 11 个主要数据库中搜索到的有关老年患者肺癌的研究、系统性综述、书籍章节和临床试验报告的结果，重点关注老年评估和生物标志物。老年肺癌的关键预后因素包括生理年龄、功能能力、身体和心理并发症、虚弱、营养、状态以及 DNA 甲基化年龄等生物标志物。我们确定了兼顾疗效和生活质量的最有价值的评估方法。对老年肺癌患者进行量身定制的治疗方法并结合复杂的老年病学评估，有利于优化护理和改善疗效。老年病学专家、肿瘤专家和肺科专家之间的多学科合作至关重要。
期刊介绍：
• Geriatric biology
• Geriatric health services research
• Geriatric medicine research
• Geriatric neurology, stroke, cognition and oncology
• Geriatric surgery
• Geriatric physical functioning, physical health and activity
• Geriatric psychiatry and psychology
• Geriatric nutrition
• Geriatric epidemiology
• Geriatric rehabilitation
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