Gastrointestinal disease in systemic sclerosis: the neglected organ system?

IF 5.2 2区 医学 Q1 RHEUMATOLOGY
Zsuzsanna McMahan, John Pandolfino, Harris Perlman, Francesco Del Galdo, Monique Hinchcliff
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引用次数: 0

Abstract

Purpose of review: Identifying outcomes and clinical trial endpoints enabled the discovery of new inflammatory bowel disease (IBD) treatments. Herein, we describe efforts to advance the study of gastrointestinal (GI) manifestations in systemic sclerosis (SSc).

Recent findings: Insights into the scope of the problem, as well as advancements in the measurement and treatment of SSc-GI, are underway. Proposed SSc esophageal endophenotypes are now defined, risk stratification methods are growing, and imaging and functional studies are now employed to guide therapeutic interventions. Additional progress is being made in characterizing the gut microbiome in patients with SSc. Research into the role of the immune response in the pathogenesis of SSc-GI disease is also ongoing, evolving simultaneously with the development of methods to facilitate data collection with real-time capture of diet, exercise, and medication data.

Summary: Multidisciplinary teams are working to deepen our understanding of SSc-GI disease pathogenesis, to identify biomarkers for risk stratification and the assessment of disease activity, and to develop and validate outcomes and clinical trial endpoints to pave the way toward effective therapy for SSc-GI disease.

系统性硬化症的胃肠道疾病:被忽视的器官系统?
综述目的:确定结果和临床试验终点有助于发现新的炎症性肠病(IBD)治疗方法。在此,我们将介绍为推动系统性硬化症(SSc)胃肠道(GI)表现的研究而做出的努力:最近的发现:我们正在深入了解这一问题的范围,并在 SSc-GI 的测量和治疗方面取得进展。目前已确定了拟议的 SSc 食管内型,风险分层方法也在不断发展,成像和功能研究已被用于指导治疗干预。在确定 SSc 患者肠道微生物组的特征方面也取得了进展。对免疫反应在 SSc-GI 疾病发病机制中的作用的研究也在进行中,与此同时,通过实时采集饮食、运动和用药数据来促进数据收集的方法也在不断发展。总结:多学科团队正在努力加深我们对 SSc-GI 疾病发病机制的了解,确定用于风险分层和疾病活动评估的生物标志物,并开发和验证结果和临床试验终点,为 SSc-GI 疾病的有效治疗铺平道路。
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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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