Multimodal treatment according to the NPC-GPOH trials in adult patients with nasopharyngeal cancer—Analysis based on a single-center experience

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-27 DOI:10.1002/cnr2.2111

Martin Leu, Hanibal Bohnenberger, Manuel Guhlich, Markus Anton Schirmer, Yiannis Pilavakis, Hendrik Andreas Wolff, Stefan Rieken, Leif Hendrik Dröge

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Abstract

Background and Aim

The German NPC-GPOH trials introduced treatment including neoadjuvant chemotherapy, radiochemotherapy (RCT) and antiviral treatment in patients aged 25 years or younger with nasopharyngeal cancer (NPC). We conducted a retrospective study on outcomes of patients at the age of ≥26 years treated accordingly at our institution.

Methods

Consecutive patients who received primary RCT for NPC were included. The Kaplan–Meier method was used to calculate survival probabilities, and the Cox regression analysis was used to test for an influence of the variables on outcomes. Acute and late toxicity were evaluated via CTCAE criteria and LENT/SOMA criteria, respectively.

Results

In total, 30 patients were included. Diagnosis was made from 09/1994 to 11/2016. The median 5 year overall survival (OS), disease-free survival (DFS), cancer-specific survival (CSS) and locoregional recurrence-free survival (LRC) were 75%, 56%, 83%, and 85%, respectively. We found a negative impact on outcomes (p < .05) in case of older age (OS), history of smoking (OS), and T4 stage/ UICC stage IV (DFS). WHO histologic type significantly influenced outcomes, with best outcomes for type III and worst outcomes for type I. The rates of acute and late toxicities were acceptable.

Conclusion

We found excellent outcomes and good feasibility of the NPC-GPOH trials regimen in adult patients. Additionally, we identified patients with outcomes which need to be improved (smokers, histologic type I tumors) and with particularly excellent outcomes (histologic type III tumors). This stimulates further studies on treatment intensification or de-escalation aiming at reduced side effects with optimal tumor control in NPC.

Abstract Image

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根据 NPC-GPOH 试验对成年鼻咽癌患者进行多模式治疗--基于单中心经验的分析。

背景和目的：德国 NPC-GPOH 试验为 25 岁或以下的鼻咽癌（NPC）患者引入了包括新辅助化疗、放射化学治疗（RCT）和抗病毒治疗在内的治疗方法。我们对本机构接受相应治疗的≥26岁患者的疗效进行了回顾性研究：方法：纳入接受鼻咽癌初治 RCT 的连续患者。采用 Kaplan-Meier 法计算生存概率，并采用 Cox 回归分析检验变量对疗效的影响。急性和晚期毒性分别按照CTCAE标准和LENT/SOMA标准进行评估：共纳入 30 名患者。确诊时间为 1994 年 9 月至 2016 年 11 月。中位5年总生存率（OS）、无病生存率（DFS）、癌症特异性生存率（CSS）和无局部复发生存率（LRC）分别为75%、56%、83%和85%。我们发现这对疗效有负面影响（P我们发现，NPC-GPOH 试验方案在成年患者中具有出色的疗效和良好的可行性。此外，我们还发现了一些疗效有待提高的患者（吸烟者、组织学 I 型肿瘤）和疗效特别好的患者（组织学 III 型肿瘤）。这促使我们进一步研究加强治疗或降低治疗强度，以减少副作用并达到最佳肿瘤控制效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.