Association between mean platelet volume and the risk of type 2 diabetes mellitus among women with history of gestational diabetes mellitus.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2024-08-27 DOI:10.1186/s12902-024-01693-3

Yiling Wei, Yanting Lin, Lili Huang, Caihong Wang, Ruiman Li

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Abstract

Aims: The present study aimed to investigate the relationship between mean platelet volume (MPV) and the risk of type 2 diabetes mellitus (T2DM), among women with and without a history of gestational diabetes mellitus (GDM).

Methods: Eight thousand one hundred eighty-one parous women of the '2007-2018 National Health and Nutrition Examination Survey (NHANES)' were classified into GDM and non-GDM groups based on self-reported GDM history. We investigated the independent association between the MPV and the risk of T2DM in these groups via multivariable regression analysis. A subgroup analysis was done for the GDM group.

Results: After comprehensive adjustment for potential covariates, a significant positive correlation was observed between MPV and the risk of T2DM in women with a history of GDM (OR = 1.50, 95% CI 1.13-2.01, P = 0.006). There was a linear relationship between MPV and T2DM among women with a history of GDM, with each unit increase in MPV increasing the risk of T2DM by 50%. Subgroup analysis and interaction tests revealed a stronger significant effect on women with GDM history who had HbA1c ≥ 7%.

Conclusions: MPV is strongly associated with the incidence of T2DM among U.S. parous women with prior GDM, indicating that MPV may be a potential biomarker of T2DM among women with a history of GDM.

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有妊娠糖尿病史的妇女的平均血小板体积与罹患 2 型糖尿病风险之间的关系。

目的：本研究旨在调查有妊娠糖尿病（GDM）病史和无妊娠糖尿病（GDM）病史妇女的平均血小板体积（MPV）与2型糖尿病（T2DM）风险之间的关系：在 "2007-2018 年美国国家健康与营养调查（NHANES）"中，8181 名准妊娠妇女根据自我报告的妊娠糖尿病史被分为妊娠糖尿病组和非妊娠糖尿病组。我们通过多变量回归分析研究了这些组别中 MPV 与 T2DM 风险之间的独立关联。我们还对 GDM 组进行了亚组分析：结果：在对潜在的协变量进行全面调整后，观察到有 GDM 病史的妇女的 MPV 与 T2DM 风险之间存在显著的正相关性（OR = 1.50，95% CI 1.13-2.01，P = 0.006）。在有 GDM 病史的妇女中，MPV 与 T2DM 呈线性关系，MPV 每增加一个单位，T2DM 的风险就增加 50%。亚组分析和交互检验显示，对 HbA1c ≥ 7% 的有 GDM 病史的妇女有更显著的影响：MPV与曾患过GDM的美国准女性中T2DM的发病率密切相关，表明MPV可能是曾患过GDM的女性中T2DM的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.

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