Yin-Hao Wang, Bo Gao, Juan Li, Long-Wei Wei, Wei Chen
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引用次数: 0
Abstract
Parkinson's disease (PD), a prevalent neurodegenerative condition, manifests predominantly through the degeneration of nigrostriatal dopaminergic (DA) pathways, culminating in a notable depletion of striatal dopamine. This pathophysiological process critically impairs the DA-mediated regulation of motor behaviors within the basal ganglia circuitry, particularly impacting various subtypes of striatal medium spiny neurons. Recent advancements in neuroscientific research have illuminated the pivotal role of D2-dopamine receptor expressing medium spiny neurons (D2-MSNs) plasticity in coordinating motor control in PD. Intriguingly, aerobic exercise emerges as a potent therapeutic intervention, capable of preventing or improving motor impairments. This ameliorative effect is mediated through the modulation of DA receptor activity and the consequent activation of downstream extracellular signal-regulated kinase (Erk) signaling pathway. This article meticulously reviewed the intricate regulatory mechanisms governing the structural and functional plasticity of striatal D2-MSNs in the context of PD. It particularly emphasized the transformative impact of aerobic exercise on motor deficits in PD, attributing this effect to the modulation of striatal D2-MSNs.
帕金森病(PD)是一种常见的神经退行性疾病,主要表现为黑质纹状体多巴胺能(DA)通路变性,最终导致纹状体多巴胺明显耗竭。这一病理生理过程严重损害了基底神经节回路中由 DA 介导的运动行为调节功能,尤其影响到纹状体中刺神经元的各种亚型。神经科学研究的最新进展表明,D2-多巴胺受体表达中刺神经元(D2-MSNs)的可塑性在协调运动控制方面对帕金森病起着关键作用。耐人寻味的是,有氧运动是一种有效的治疗干预措施,能够预防或改善运动障碍。这种改善作用是通过调节DA受体的活性以及随之激活下游的细胞外信号调节激酶(Erk)信号通路来实现的。这篇文章细致回顾了在帕金森病背景下支配纹状体D2-MSNs结构和功能可塑性的复杂调控机制。文章特别强调了有氧运动对帕金森病运动障碍的改变性影响,并将这种影响归因于对纹状体D2-MSNs的调节。
期刊介绍:
Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.