[Research progress of KCNJ5 gene in aldosterone-producing adenoma].

Q3 Medicine
生理学报 Pub Date : 2024-08-25
Guan-Jun Jia, Hong-Ying Lyu, Ming-Shuang Hou, Qian-Qian Chen, Jing Xu, Yong-Xiang Li, Meng-Yao Li, Yu-Shun Kou, Rui-Ling Ma, Zheng-Jie Teng, Lin Yi
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引用次数: 0

Abstract

Aldosterone-producing adenoma is a subtype of primary aldosteronism. Recent advancements in multi-omics research have led to significant progress in understanding primary aldosteronism at the genetic level. Among the various genes associated with the development of aldosterone-producing adenomas, the KCNJ5 (potassium inwardly rectifying channel, subfamily J, member 5) gene has received considerable attention due to its prevalence as the most common somatic mutation gene in primary aldosteronism. This paper aims to integrate the existing evidence on the involvement of KCNJ5 gene in the pathogenesis of aldosterone-producing adenomas, to enhance the understanding of the underlying mechanisms of aldosterone-producing adenomas from the perspective of genetics, and to provide novel insights for the clinical diagnosis and treatment of aldosterone-producing adenomas.

[醛固酮腺瘤中 KCNJ5 基因的研究进展]。
醛固酮生成腺瘤是原发性醛固酮增多症的一种亚型。多组学研究的最新进展使人们在基因层面了解原发性醛固酮增多症方面取得了重大进展。在与醛固酮生成腺瘤发病相关的各种基因中,KCNJ5(钾内向整流通道,J亚家族,成员5)基因因其作为原发性醛固酮增多症最常见的体细胞突变基因而受到广泛关注。本文旨在整合KCNJ5基因参与醛固酮分泌性腺瘤发病机制的现有证据,从遗传学的角度加深对醛固酮分泌性腺瘤内在机制的认识,并为醛固酮分泌性腺瘤的临床诊断和治疗提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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