Duration of peripheral nerve blocks in opioid-tolerant individuals: A study protocol.

IF 1.9 4区 医学 Q2 ANESTHESIOLOGY
Acta Anaesthesiologica Scandinavica Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI:10.1111/aas.14513
Mikkel Schjødt Heide Jensen, Johan Kløvgaard Sørensen, Lone Nikolajsen, Charlotte Runge
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引用次数: 0

Abstract

Background: Peripheral nerve blocks effectively alleviate postoperative pain. Animal studies and human research suggest that opioid tolerance may reduce the effectiveness of local analgesics. The reduced effectiveness has been observed in opioid-tolerant humans and animals undergoing spinal and infiltration anaesthesia with both lidocaine and bupivacaine. However, the impact on peripheral nerve blocks in humans has not been evaluated. This study aims to assess the onset time and duration of a radial nerve block in opioid-tolerant individuals compared to opioid-naive individuals. We hypothesise that peripheral nerve blocks may be less effective in producing sensory and motor blockades in opioid-tolerant individuals compared to their opioid-naive counterparts.

Methods: Twenty opioid-tolerant individuals will be matched by sex and age with opioid-naïve counterparts. Participants will receive an ultrasound-guided radial nerve block. The primary outcome is the difference in the duration of sensory nerve blockade between the two groups. The secondary outcomes include the onset time of sensory blockade, onset time of motor blockade, and difference in duration of motor nerve blockade.

Conclusion: This study will compare the effectiveness of a peripheral nerve block between opioid-tolerant and opioid-naïve individuals. Any found differences could support a specific postoperative protocol for opioid-tolerant individuals regarding the use of peripheral nerve blocks.

阿片类药物耐受者外周神经阻滞的持续时间:研究方案。
背景介绍周围神经阻滞能有效缓解术后疼痛。动物实验和人体研究表明,阿片类药物耐受性可能会降低局部镇痛药的效果。在使用利多卡因和布比卡因进行脊髓麻醉和浸润麻醉时,已观察到对阿片类药物有耐受性的人类和动物的镇痛效果降低。然而,尚未评估其对人类周围神经阻滞的影响。本研究旨在评估阿片耐受者与阿片不耐受者桡神经阻滞的起始时间和持续时间。我们假设,与未服用阿片类药物的人相比,对阿片类药物有耐受性的人的外周神经阻滞在产生感觉和运动阻滞方面可能效果较差:方法: 20 名阿片耐受者将与阿片无效者按性别和年龄进行配对。参与者将接受超声引导下的桡神经阻滞。主要结果是两组患者感觉神经阻滞持续时间的差异。次要结果包括感觉阻滞开始时间、运动阻滞开始时间和运动神经阻滞持续时间的差异:本研究将比较阿片类药物耐受者和阿片类药物无效者的外周神经阻滞效果。任何发现的差异都将有助于为阿片耐受者制定特定的术后外周神经阻滞方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.30
自引率
9.50%
发文量
157
审稿时长
3-8 weeks
期刊介绍: Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.
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