Amine-bearing hydrocarbon cross-links: Tailoring helix stability, hydrophilicity, and synthetic adaptability in peptides

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2024-08-22 DOI:10.1016/j.bmc.2024.117893

Duc V.H. Tran, Thanh K. Pham, Young-Woo Kim

引用次数: 0

Abstract

This study comprehensively explored the helix-stabilizing effects of amine-bearing hydrocarbon cross-links (ABXs), revealing their context-dependent nature influenced by various structural parameters. Notably, we identified a 9-atom ABX as a robust helix stabilizer, showcasing versatile synthetic adaptability while preserving peptide water solubility. Future investigations are imperative to fully exploit this system’s potential and enrich our chemical toolkit for designing innovative peptide-based biomolecules.

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含胺烃交联：定制肽的螺旋稳定性、亲水性和合成适应性

本研究全面探讨了含胺碳氢化合物交联（ABX）的螺旋稳定作用，揭示了它们受各种结构参数影响的环境依赖性。值得注意的是，我们发现了一种 9 原子 ABX，它是一种强效的螺旋稳定剂，在保持肽水溶性的同时，展示了多方面的合成适应性。未来的研究工作势在必行，以充分挖掘该系统的潜力，并丰富我们的化学工具包，从而设计出基于多肽的创新型生物大分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.