Novel drug delivery systems in colorectal cancer: Advances and future prospects

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-08-21 DOI:10.1016/j.prp.2024.155546

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引用次数: 0

Abstract

Colorectal cancer (CRC) is an abnormal proliferation of cells within the colon and rectum, leading to the formation of polyps and disruption of mucosal functions. The disease development is influenced by a combination of factors, including inflammation, exposure to environmental mutagens, genetic alterations, and impairment in signaling pathways. Traditional treatments such as surgery, radiation, and chemotherapy are often used but have limitations, including poor solubility and permeability, treatment resistance, side effects, and post-surgery issues. Novel Drug Delivery Systems (NDDS) have emerged as a superior alternative, offering enhanced drug solubility, precision in targeting cancer cells, and regulated drug release. Thereby addressing the shortcomings of conventional therapies and showing promise for more effective CRC management. The present review sheds light on the pathogenesis, signaling pathways, biomarkers, conventional treatments, need for NDDS, and application of NDDS against CRC. Additionally, clinical trials, ongoing clinical trials, marketed formulations, and patents on CRC are also covered in the present review.

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结直肠癌的新型给药系统：进展与前景

大肠癌（CRC）是结肠和直肠内细胞的异常增殖，导致息肉的形成和粘膜功能的破坏。疾病的发展受多种因素的影响，包括炎症、暴露于环境诱变剂、基因改变和信号通路受损。手术、放疗和化疗等传统治疗方法经常被采用，但存在溶解性和渗透性差、耐药性、副作用和术后问题等局限性。新型给药系统（NDDS）可提高药物溶解度，精确靶向癌细胞，并可调节药物释放，是一种优越的替代疗法。新型给药系统（NDDS）具有更强的药物溶解性、靶向癌细胞的精确性和药物释放的可调控性，从而弥补了传统疗法的不足，并有望更有效地治疗 CRC。本综述阐明了 CRC 的发病机制、信号传导途径、生物标志物、传统治疗方法、对 NDDS 的需求以及 NDDS 在 CRC 中的应用。此外，本综述还涵盖了有关 CRC 的临床试验、正在进行的临床试验、上市制剂和专利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.