Making and Selecting the Best Embryo in In vitro Fertilization

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Rocío Nuñez-Calonge , Nuria Santamaria , Teresa Rubio , Juan Manuel Moreno
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引用次数: 0

Abstract

Currently, most assisted reproduction units transfer a single embryo to avoid multiple pregnancies. Embryologists must select the embryo to be transferred from a cohort produced by a couple during a cycle. This selection process should be accurate, non-invasive, inexpensive, reproducible, and available to in vitro fertilization (IVF) laboratories worldwide.

Embryo selection has evolved from static and morphological criteria to the use of morphokinetic embryonic characteristics using time-lapse systems and artificial intelligence, as well as the genetic study of embryos, both invasive with preimplantation genetic testing for aneuploidies (PGT-A) and non-invasive (niPGT-A). However, despite these advances in embryo selection methods, the overall success rate of IVF techniques remains between 25 and 30%. This review summarizes the different methods and evolution of embryo selection, their strengths and limitations, as well as future technologies that can improve patient outcomes in the shortest possible time. These methodologies are based on procedures that are applied at different stages of embryo development, from the oocyte to the cleavage and blastocyst stages, and can be used in laboratory routine.

在体外受精中制作和选择最佳胚胎
目前,大多数辅助生殖单位只移植一个胚胎,以避免多胎妊娠。胚胎学家必须从一对夫妇在一个周期内产生的胚胎群中选择要移植的胚胎。胚胎选择已从静态和形态学标准发展到使用延时系统和人工智能的形态动力学胚胎特征,以及胚胎遗传学研究,包括植入前非整倍体基因检测(PGT-A)和非侵入性检测(niPGT-A)。然而,尽管胚胎选择方法取得了这些进步,试管婴儿技术的总体成功率仍在 25% 到 30% 之间。本综述总结了胚胎选择的不同方法和演变、它们的优势和局限性,以及能在最短时间内改善患者预后的未来技术。这些方法基于胚胎发育的不同阶段(从卵母细胞到卵裂和囊胚阶段)所采用的程序,可用于实验室常规操作。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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