Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

IF 4 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Hao CHEN , Yang ZHOU , Haiping HAO , Jing XIONG
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引用次数: 0

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver disease globally. It initiates with simple steatosis (NAFL) and can progress to the more severe condition of non-alcoholic steatohepatitis (NASH). NASH often advances to end-stage liver diseases such as liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Notably, the transition from NASH to end-stage liver diseases is irreversible, and the precise mechanisms driving this progression are not yet fully understood. Consequently, there is a critical need for the development of effective therapies to arrest or reverse this progression. This review provides a comprehensive overview of the pathogenesis of NASH, examines the current therapeutic targets and pharmacological treatments, and offers insights for future drug discovery and development strategies for NASH therapy.

非酒精性脂肪性肝炎的新机制和新型药物疗法
非酒精性脂肪肝(NAFLD)已成为全球慢性肝病的主要病因。非酒精性脂肪肝最初表现为单纯性脂肪变性(NAFL),随后可发展为更严重的非酒精性脂肪性肝炎(NASH)。非酒精性脂肪性肝炎通常会发展为肝纤维化、肝硬化和肝细胞癌(HCC)等终末期肝病。值得注意的是,从 NASH 到终末期肝病的转变是不可逆的,而驱动这一进展的确切机制尚未完全明了。因此,亟需开发有效的疗法来阻止或逆转这一进展。本综述全面概述了 NASH 的发病机制,研究了当前的治疗靶点和药物治疗方法,并对未来 NASH 治疗药物的发现和开发策略提出了见解。
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来源期刊
Chinese Journal of Natural Medicines
Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.50
自引率
4.30%
发文量
2235
期刊介绍: The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.
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