The Role of Inflammation in Depression and Beyond: A Primer for Clinicians.

IF 5.5 2区 医学 Q1 PSYCHIATRY
Current Psychiatry Reports Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI:10.1007/s11920-024-01526-z
Eduardo Andres Calagua-Bedoya, Vignesh Rajasekaran, Lotje De Witte, M Mercedes Perez-Rodriguez
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Abstract

Purpose of review: We evaluate available evidence for the role of inflammation in depression. We reappraise literature involving systemic inflammation, neuroinflammation and neurotransmission and their association with depression. We review the connection between depression, autoimmunity and infectious diseases. We revise anti-inflammatory treatments used in depression.

Recent findings: Peripheral inflammatory markers are present in a subset of patients with depression and can alter common neurotransmitters in this population but there is no clear causality between depression and systemic inflammation. Infectious conditions and autoimmune illnesses do not have a clear correlation with depression. Certain medications have positive evidence as adjunctive treatments in depression but studies are heterogenic, hence they are sparsely used in clinical settings. The current evidence does not fully support inflammation, infections or autoimmunity as possible etiologies of depression. The available studies have numerous confounders that obscure the findings. Anti-inflammatory agents may have potential for treatment of depression, but further research is needed to clarify their usefulness in routine clinical practice.

Abstract Image

炎症在抑郁症及其他疾病中的作用:临床医生入门指南》。
综述的目的:我们评估了炎症在抑郁症中作用的现有证据。我们重新评估了涉及全身炎症、神经炎症和神经递质及其与抑郁症关系的文献。我们回顾了抑郁症、自身免疫和传染病之间的联系。我们修订了用于抑郁症的抗炎治疗方法:最近的研究结果:外周炎症标志物存在于部分抑郁症患者中,并可改变这类人群中常见的神经递质,但抑郁症与全身炎症之间没有明确的因果关系。感染性疾病和自身免疫性疾病与抑郁症没有明确的相关性。某些药物作为抑郁症的辅助治疗手段具有积极的证据,但研究结果不一,因此在临床上使用较少。目前的证据并不完全支持将炎症、感染或自身免疫作为抑郁症的可能病因。现有的研究有许多混杂因素,模糊了研究结果。抗炎药物可能具有治疗抑郁症的潜力,但还需要进一步研究,以明确其在常规临床实践中的作用。
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来源期刊
CiteScore
11.30
自引率
3.00%
发文量
68
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published research in psychiatry. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by psychiatric disorders. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anxiety, medicopsychiatric disorders, and schizophrenia and other related psychotic disorders. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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