Incidence and risk factors of VTE in lung cancer: a meta-analysis.

Annals of medicine Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI:10.1080/07853890.2024.2390200

Ruiyuan Yang, Haoyu Wang, Dan Liu, Weimin Li

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Abstract

Background: Lung cancer has maintained a high prevalence and mortality. Besides, venous thromboembolism (VTE) is the third most common disease of cardiovascular disease. Lung cancer with VTE usually influenced the overall survival in the follow-up. In the development of lung cancer, vigilance against and early diagnosis of VTE is of significance.

Methods: We searched the databases of PubMed, Web of Science, Embase and Cochrane for related research up to 30 November 2023 and extracted information of incidence, odds ratio (OR), hazard ratio (HR) and their 95% confidence intervals (CIs), for evaluating the incidence of VTE and its risk factors.

Results: A total of 54 articles and 873,292 records were included in our study. The pooled incidences of VTE and PE were 6% and 3%, respectively. Subgroup analysis revealed that the tumour, node and metastasis (TNM) stage (HR= 5.43, 95% CI: 2.42, 12.22), metastasis (HR= 2.67, 95% CI: 1.35, 5.29) and chemotherapy (HR= 2.27, 95% CI: 1.11, 4.65) had major influence on VTE occurrence.

Conclusions: Lung cancer complicated with VTE is unignorable, and its occurrence varies widely by tumour staging, tissue type and treatment. The results may aid in clinical decision-making about lung cancer in higher risk with VTE and weather receiving anticoagulant prophylaxis.

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肺癌 VTE 的发生率和风险因素：一项荟萃分析。

背景：肺癌的发病率和死亡率一直居高不下。此外，静脉血栓栓塞症（VTE）是心血管疾病中第三大常见疾病。肺癌合并 VTE 通常会影响随访的总生存率。在肺癌的发展过程中，警惕和早期诊断 VTE 具有重要意义：方法：我们检索了PubMed、Web of Science、Embase和Cochrane等数据库中截至2023年11月30日的相关研究，提取了VTE的发病率、几率比（OR）、危险比（HR）及其95%置信区间（CI）等信息，以评估VTE的发病率及其危险因素：研究共纳入 54 篇文章和 873 292 条记录。VTE和PE的总发生率分别为6%和3%。亚组分析显示，肿瘤、结节和转移（TNM）分期（HR= 5.43，95% CI：2.42，12.22）、转移（HR= 2.67，95% CI：1.35，5.29）和化疗（HR= 2.27，95% CI：1.11，4.65）对 VTE 的发生有主要影响：结论：肺癌并发 VTE 是不可逆的，其发生率因肿瘤分期、组织类型和治疗方法的不同而有很大差异。研究结果有助于对肺癌并发 VTE 的高危人群和接受抗凝剂预防的天气做出临床决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of medicine

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