Ninjinyoeito ameliorates anorexia and changes in peptide YY and ghrelin levels of cisplatin-treated mice

IF 2.5 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Akinobu Hatae, Takuya Watanabe, Chise Taniguchi, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki
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Abstract

We explored the effect of Ninjinyoeito (NYT) on cisplatin-induced anorexia, which reduces cancer patient survival. Both gastrointestinal motility and plasma concentrations of gastrointestinal peptides were assessed. Nine-week-old ICR female mice received intraperitoneal cisplatin injections (10 mg/kg) and daily oral NYT doses of 300 mg/kg (NYT300) or 1000 mg/kg (NYT1000). Plasma levels of gastrointestinal peptides were measured at 3 and 6 days after cisplatin injection. Gastrointestinal motility was assessed by analyzing the concentration of phenol red marker within sections of the gastrointestinal tract. Cisplatin-injected mice showed a decrease in daily food intake, but this effect was attenuated on day 5 with NYT1000 administration. Although plasma ghrelin levels were reduced on day 3 in cisplatin-treated mice, NYT1000 administration ameliorated this decrease. However, there were no differences in ghrelin levels among all groups on day 6. Levels of peptide YY (PYY) were elevated in the plasma of cisplatin-injected mice on days 3 and 6. Administration of NYT300 and NYT1000 suppressed the increase in PYY levels on day 6 but not on day 3. Gastrointestinal motility was impaired on day 6 in cisplatin-treated mice, but NYT1000 administration attenuated this effect. Our results suggest that NYT improves cisplatin-induced anorexia by suppressing alterations in ghrelin and PYY levels and by increasing gastrointestinal motility. Therefore, NYT may be a promising candidate for alleviating cisplatin-induced anorexia.

万年青能改善顺铂治疗小鼠的厌食症以及肽 YY 和胃泌素水平的变化。
顺铂会降低癌症患者的生存率,我们探讨了万年青(NYT)对顺铂诱发的厌食症的影响。我们对胃肠道蠕动和胃肠道肽的血浆浓度进行了评估。9周大的ICR雌性小鼠腹腔注射顺铂(10毫克/千克),每天口服300毫克/千克(NYT300)或1000毫克/千克(NYT1000)剂量的NYT。顺铂注射后3天和6天测量血浆中胃肠道肽的水平。通过分析胃肠道切片中酚红标记物的浓度来评估胃肠道蠕动。顺铂注射小鼠的日摄食量有所下降,但在第5天服用NYT1000后,这种影响有所减弱。虽然顺铂治疗小鼠的血浆胃泌素水平在第3天有所下降,但服用NYT1000后这种下降趋势得到了改善。然而,在第 6 天,各组之间的胃泌素水平没有差异。顺铂注射小鼠血浆中的肽YY(PYY)水平在第3天和第6天升高。服用 NYT300 和 NYT1000 可抑制第 6 天PYY 水平的升高,但不能抑制第 3 天PYY 水平的升高。顺铂治疗小鼠的胃肠道运动在第6天受到损害,但服用NYT1000可减轻这种影响。我们的研究结果表明,NYT可通过抑制胃泌素和PYY水平的变化以及增加胃肠道蠕动来改善顺铂诱导的厌食症。因此,NYT可能是缓解顺铂诱导的厌食症的一种有希望的候选药物。
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来源期刊
Neuropeptides
Neuropeptides 医学-内分泌学与代谢
CiteScore
5.40
自引率
6.90%
发文量
55
审稿时长
>12 weeks
期刊介绍: The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
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