High rates of anal Merkel Cell Polyomavirus and HPV co-infection among people living with HIV

IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2024-08-26 DOI:10.1002/jmv.29883

Sara Passerini, Matteo Fracella, Domenico Benvenuto, Ginevra Bugani, Alessandra D'Auria, Eleonora Coratti, Giulia Babini, Ugo Moens, Eugenio Nelson Cavallari, Carlo Torti, Guido Antonelli, Massimo Ciccozzi, Alessandra Pierangeli, Gabriella d'Ettorre, Carolina Scagnolari, Valeria Pietropaolo

引用次数: 0

Abstract

Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high-risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).

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艾滋病病毒感染者中肛门梅克尔细胞多瘤病毒和人乳头瘤病毒合并感染率高。

人们对肛门部位人类多瘤病毒（HPyV）感染及其与人类乳头状瘤病毒（HPV）和人类免疫缺陷病毒（HIV）等性传播感染的关系的了解仍然有限。因此，我们对 150 例男女患者的肛门标本进行了筛查分析。在 50.7% 的病例中发现了 HPV DNA，其中以高风险（HR）基因型为主。在 39.3% 的样本中发现了 HPyV DNA，其中梅克尔细胞多瘤病毒（MCPyV）最为常见，其病毒载量高于 JCPyV 和 BKPyV。此外，在感染 HPV 的艾滋病病毒感染者（PLWH）中，MCPyV 病毒载量增加（p

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.

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