Hypochlorous Acid for Wound Healing in Diabetic Rats: Effect on MMP-9 and Histology.

IF 1.9 4区 医学 Q3 DERMATOLOGY
Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-19 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S468494
Dita Mutiara Irawan, Ronny Lesmana, Edhyana Sahiratmadja
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引用次数: 0

Abstract

Background: People who suffered type 2 diabetes have impaired healing of wounds due to the large number of circulating inflammatory cells resulting from high blood sugar levels. The wound healing process involves various complex processes including the degradation of extracellular matrix, a process characterized by an increase in matrix metalloproteinase-9 (MMP-9). Conventional management of diabetic wounds usually involves systemic blood sugar control and topical antimicrobial treatment, including hydrogen peroxide and povidone-iodine, which are known to be cytotoxic to the cells involved in the wound healing cascade. Finding a safe, non-toxic, and effecting wound cleansing still poses a challenge, and hypochlorous acid (HOCl) could act as a potential candidate.

Purpose: Unveiling an HOCl ion as an agent for diabetic wound management and MMP-9 as a marker for delayed diabetic wound healing.

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Flow Diagram is used to find and select related, eligible literatures for the review. The authors used several databases such as Pro Quest, Scopus, Springer link and Science Direct. In addition, and to expand the data, the database on Google Scholar was also opened. Then, the compiled data are analyzed to form results and discussions to the research question.

Results: Five eligible articles passed the inclusion criteria and reviewed for data synthesis. From 5 pieces of literature, it was found that the use of HOCl ions can be a good choice of topical agent in the management of diabetic wounds and decrease the activity of MMP-9, which act as a marker for delayed healing of diabetic wounds.

Conclusion: Topical agent, in this case HOCl ion, shows good results and can be used as an option in the management of diabetic wounds and MMP-9 can be used as a predictive marker in the management of diabetic wounds.

次氯酸促进糖尿病大鼠伤口愈合:对 MMP-9 和组织学的影响
背景:由于高血糖导致大量循环炎症细胞,2 型糖尿病患者的伤口愈合能力受损。伤口愈合过程涉及各种复杂的过程,包括细胞外基质的降解,这一过程的特点是基质金属蛋白酶-9(MMP-9)的增加。糖尿病伤口的传统治疗方法通常包括全身血糖控制和局部抗菌治疗,包括过氧化氢和聚维酮碘,众所周知,过氧化氢和聚维酮碘对参与伤口愈合级联的细胞具有细胞毒性。寻找一种安全、无毒、有效的伤口清洁剂仍是一项挑战,而次氯酸(HOCl)可作为一种潜在的候选药物。目的:揭示作为糖尿病伤口管理药物的 HOCl 离子和作为糖尿病伤口延迟愈合标志物的 MMP-9:方法:采用系统综述和荟萃分析首选报告项目(PRISMA)流程图查找并选择符合条件的相关文献进行综述。作者使用了多个数据库,如 Pro Quest、Scopus、Springer link 和 Science Direct。此外,为了扩展数据,作者还打开了谷歌学术(Google Scholar)数据库。然后,对汇编的数据进行分析,形成结果并针对研究问题进行讨论:结果:5 篇符合条件的文章通过了纳入标准,并进行了数据综合审查。从 5 篇文献中发现,使用 HOCl 离子可以很好地选择外用药物来治疗糖尿病伤口,并降低作为糖尿病伤口延迟愈合标志的 MMP-9 的活性:外用药剂(本例中为 HOCl 离子)显示出良好的效果,可作为治疗糖尿病伤口的一种选择,MMP-9 可作为治疗糖尿病伤口的预测指标。
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来源期刊
CiteScore
2.80
自引率
4.30%
发文量
353
审稿时长
16 weeks
期刊介绍: Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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