Interferon Gamma in Sickness Predisposing to Mycobacterial Infectious Diseases

IF 1.9 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Balkan Medical Journal Pub Date : 2024-09-06 Epub Date: 2024-08-26 DOI:10.4274/balkanmedj.galenos.2024.2024-8-18

Betül Gemici Karaaslan, Jérémie Rosain, Jacinta Bustamante, Ayça Kıykım

引用次数: 0

Abstract

In recent decades, the prevalence of inborn errors of immunity has increased, necessitating the development of more effective treatment and care options for these highly morbid conditions. Due to these “experiments of nature,” the complicated nature of the immune system is being revealed. Based on the functional and molecular tests, targeted therapies are now being developed which offer a more effective approach and reduce damage. This study aimed to investigate a key cytokine of the cellular immune response, interferon‐gamma (IFN-γ), which is linked to Mendelian susceptibility to Mycobacterial disease, and its potential as a therapeutic option for IFN-γ deficiency.

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干扰素γ在易患分枝杆菌传染病的疾病中的作用

近几十年来，先天性免疫错误的发病率不断上升，因此有必要针对这些高发病率疾病开发更有效的治疗和护理方案。由于这些 "大自然的实验"，免疫系统的复杂本质逐渐被揭示出来。基于功能和分子测试，目前正在开发靶向疗法，以提供更有效的方法并减少损害。本研究旨在研究细胞免疫反应的一种关键细胞因子--γ干扰素（IFN-γ），它与孟德尔分枝杆菌病的易感性有关，并研究其作为 IFN-γ 缺乏症治疗方案的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Balkan Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

4.10

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English. The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based. The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.