Assessment of myocardial injury by SPECT myocardial perfusion imaging in patients with COVID-19 infection in a single center after lifting the restrictions in China

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Annals of Nuclear Medicine Pub Date : 2024-08-26 DOI:10.1007/s12149-024-01970-0

Keke Xin, Xinghong Ma, Xiaoli Meng, Xiao Zhang, Weidong Yang, Taoqi Ma, Cheng Zhou, Jing Wang, Guoquan Li

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Abstract

Purpose

To assess myocardial injury using rest single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with COVID-19 and to evaluate whether myocardial injury detected by rest MPI predict the prognosis of symptoms after 6 months follow-up.

Methods

Patients suspected of myocarditis between December 2022 and March 2023, after the lifting of COVID-19 pandemic restrictions, and between December 2018 and March 2019, prior to the pandemic, were referred to our study. All patients underwent rest MPI. One hundred and sixty four patients with COVID-19 infection after the lifting of pandemic restrictions and 101 patients before the pandemic were included as the study and control groups, respectively. One hundred and fifty three patients of the study group and 83 of the control group presented symptoms when they initially visit to our department. Compare the parameters of myocardial injury detected by rest SPECT MPI between the two groups and then investigate the association between myocardial injury and symptom prognosis in symptomatic patients of both groups.

Results

Total perfusion defect (TPD) (4.2% ± 3.3% vs. 2.3% ± 2.2%, P < 0.001), summed rest score (SRS) (5.3 ± 5.4 vs. 2.7 ± 2.0, P < 0.001), the proportion of patients with TPD > 4% (43.3% vs. 17.8%, P < 0.001), TPD > 10% (6.71% vs 0, P < 0.001), SRS > 4 (40.2% vs 15.8%, P < 0.001), SRS > 10 (12.8% vs 0, P < 0.001), the number of abnormal perfusion segments (3.9 ± 3.1 vs. 2.4 ± 1.7, P < 0.001) were all significantly higher in the study group. All the parameters of rest MPI were not associated with the prognosis of symptoms in symptomatic patients of both groups after 6 months follow-up.

Conclusion

Myocardial injury in COVID-19 patients could be assessed by rest SPECT MPI. The COVID-19 patients could exhibited a higher frequency and greater severity of myocardial injury than uninfected control patients. Myocardial injury assessed by rest MPI did not predict for the prognosis of symptoms in symptomatic patients of both COVID-19 patients and uninfected patients.

Abstract Image

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中国取消限制后，单个中心通过SPECT心肌灌注成像评估COVID-19感染患者的心肌损伤。

目的：使用静息单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）评估COVID-19患者的心肌损伤，并评估静息MPI检测到的心肌损伤是否能预测随访6个月后症状的预后：在 COVID-19 大流行限制解除后的 2022 年 12 月至 2023 年 3 月期间，以及在大流行之前的 2018 年 12 月至 2019 年 3 月期间，疑似心肌炎患者被转介到我们的研究中。所有患者均接受了静息心动图检查。研究组和对照组分别纳入了 164 名大流行限制解除后感染 COVID-19 的患者和 101 名大流行前感染 COVID-19 的患者。研究组和对照组分别有 153 名和 83 名患者在初诊时出现症状。比较两组患者通过静息 SPECT MPI 检测到的心肌损伤参数，然后研究两组有症状患者的心肌损伤与症状预后之间的关联：总灌注缺损（TPD）（4.2% ± 3.3% vs. 2.3% ± 2.2%，P 4%（43.3% vs. 17.8%），P 10%（6.71% vs. 0），P 4%（40.2% vs. 15.8%），P 10%（12.8% vs. 0），P 结论：COVID 患者的心肌损伤与症状预后密切相关：静息 SPECT MPI 可评估 COVID-19 患者的心肌损伤。与未感染的对照组患者相比，COVID-19 患者的心肌损伤频率更高、程度更严重。通过静息 MPI 评估心肌损伤并不能预测 COVID-19 患者和未感染患者的症状预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.