Platelet Membrane-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Sildenafil for Targeted Therapy of Vein Graft Intimal Hyperplasia

IF 5.2 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Fajing Yang , Yihui Qiu , Xueting Xie , Xingjian Zhou , Shunfu Wang , Jialu Weng , Lina Wu , Yizhe Ma , Ziyue Wang , Wenzhang Jin , Bicheng Chen
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引用次数: 0

Abstract

Autologous vein grafts have attracted widespread attention for their high transplantation success rate and low risk of immune rejection. However, this technique is limited by the postoperative neointimal hyperplasia, recurrent stenosis and vein graft occlusion. Hence, we propose the platelet membrane-coated Poly(lactic-co-glycolic acid) (PLGA) containing sildenafil (PPS). Platelet membrane (PM) is characterised by actively targeting damaged blood vessels. The PPS can effectively target the vein grafts and then slowly release sildenafil to treat intimal hyperplasia in the vein grafts, thereby preventing the progression of vein graft restenosis. PPS effectively inhibits the proliferation and migration of vascular smooth muscle cell (VSMCs) and promotes the migration and vascularisation of human umbilical vein endothelial cells (HUVECs). In a New Zealand rabbit model of intimal hyperplasia in vein grafts, the PPS significantly suppressed vascular stenosis and intimal hyperplasia at 14 and 28 days after surgery. Thus, PPS represents a nanomedicine with therapeutic potential for treating intimal hyperplasia of vein grafts.

Abstract Image

含有西地那非的血小板膜包裹聚(乳酸-共-乙醇酸)纳米粒子用于静脉移植内膜增生的靶向治疗
自体静脉移植因其移植成功率高、免疫排斥风险低而受到广泛关注。然而,这种技术受到术后新血管增生、复发性狭窄和静脉移植物闭塞的限制。因此,我们提出了含有西地那非的血小板膜包覆聚乳酸-聚乙二醇酸(PLGA)(PPS)。血小板膜(PM)的特点是主动靶向受损血管。PPS 可有效靶向静脉移植物,然后缓慢释放西地那非,治疗静脉移植物内膜增生,从而防止静脉移植物再狭窄的恶化。PPS 能有效抑制血管平滑肌细胞(VSMC)的增殖和迁移,促进人脐静脉内皮细胞(HUVEC)的迁移和血管化。在新西兰兔静脉移植内膜增生模型中,PPS 能显著抑制术后 14 天和 28 天的血管狭窄和内膜增生。因此,PPS 是一种具有治疗静脉移植物内膜增生潜力的纳米药物。
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来源期刊
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
6.60
自引率
0.00%
发文量
32
审稿时长
24 days
期刊介绍: International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
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