{"title":"C(sp3)P cross-coupling of alkyl substrates with P(O)H compounds and phosphites","authors":"","doi":"10.1016/j.tetlet.2024.155266","DOIUrl":null,"url":null,"abstract":"<div><p>Alkylphosphorus compounds have been widely used in ligands, flame retardants, bioorganic and medical chemistry, agrochemicals, chelating agents, and organic synthesis. However, traditional methods for C(sp<sup>3</sup>)<img>P bond construction are somewhat unsatisfactory. In recent years, a number of outstanding phosphorylation reactions have been achieved, which might open vast opportunities for the synthesis of alkylphosphonates. This digest review covers the recent advances in C(sp<sup>3</sup>)<img>P cross-coupling reactions using readily available P(O)<img>H compounds and phosphites as phosphorus sources since 2020, and the corresponding reactions are categorized into two types according to alkyl substrates bearing C(sp<sup>3</sup>)<img>H bonds or C(sp<sup>3</sup>)<img>LG (LG = leaving group) bonds.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003617","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Alkylphosphorus compounds have been widely used in ligands, flame retardants, bioorganic and medical chemistry, agrochemicals, chelating agents, and organic synthesis. However, traditional methods for C(sp3)P bond construction are somewhat unsatisfactory. In recent years, a number of outstanding phosphorylation reactions have been achieved, which might open vast opportunities for the synthesis of alkylphosphonates. This digest review covers the recent advances in C(sp3)P cross-coupling reactions using readily available P(O)H compounds and phosphites as phosphorus sources since 2020, and the corresponding reactions are categorized into two types according to alkyl substrates bearing C(sp3)H bonds or C(sp3)LG (LG = leaving group) bonds.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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