Association between vitamin D level and cataract: A systematic review and meta-analysis.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY

Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI:10.1007/s00417-024-06592-w

Zhenzhen Jue, Ziming Xu, Vincent L Yuen, Odessa Dik San Chan, Jason C Yam

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引用次数: 0

Abstract

Purpose: The association between serum vitamin D level and cataract remains controversial. This study aims to evaluate the association between vitamin D level and cataract.

Methods: In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 30 August 2023 and 626 articles were screened. Four studies involving a total of 10,928 subjects with cataract and 10,117 control subjects met the inclusion criteria.

Results: Decreased serum vitamin D level was associated with higher incidence of cataract (P = 0.047; MD: -4.87; 95%CI: [-9.67, -0.07]). In the subgroup analysis by sex, a significant association was found between serum vitamin D level and cataract in both male (P = 0.01, MD: -2.15,95%CI: [-3.83, -0.46]) and female (P < 0.01; MD: -6.67,95%CI: [-8.20, -5.14]).In the subgroup analysis by the types of cataract, significant association was found between serum vitamin D level and nuclear (P < 0.01; MD: -10.48; 95%CI: [-12.72, -8.24]) and posterior subcapsular cataract (P = 0.02; MD: -6.05; 95%CI: [-11.30, -0.80]) but not in cortical cataract (P = 0.14; MD: -6.74; 95%CI: [-15.70, 2.22]).

Conclusion: This meta-analysis revealed potential association between serum vitamin D level and cataract, more significant in female, and the subtypes of nuclear and posterior subcapsular cataract.

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维生素 D 水平与白内障之间的关系：系统回顾与荟萃分析。

目的：血清维生素 D 水平与白内障之间的关系仍存在争议。本研究旨在评估维生素 D 水平与白内障之间的关系：本研究检索了 PubMed、Web of Science 和 EMBASE 数据库中截至 2023 年 8 月 30 日的文章，共筛选出 626 篇文章。符合纳入标准的有四项研究，共涉及 10928 名白内障患者和 10117 名对照组受试者：血清维生素 D 水平降低与白内障发病率升高有关（P = 0.047；MD：-4.87；95%CI：[-9.67, -0.07]）。在按性别进行的亚组分析中，发现男性（P = 0.01，MD：-2.15，95%CI：[-3.83，-0.46]）和女性（P 结论：男性和女性的血清维生素 D 水平与白内障之间存在显著关联：这项荟萃分析揭示了血清维生素 D 水平与白内障之间的潜在关系，女性的关系更为显著，而且还揭示了核性白内障和后囊下白内障的亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.