Comparison of Clinical Outcomes in the Slow-Developing Blastocysts With or Without Preimplantation Genetic Testing-Aneuploidy on Day 6 in the Frozen–Thawed Cycle

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada Pub Date : 2024-08-22 DOI:10.1016/j.jogc.2024.102644

Hee Jun Lee MD, PhD , Jae Eun Park MD , Jihye Jeong MS , Tae Hyung Kim BS , Sola Yoon MS , Jisoo Han PhD , Jin Hee Eum PhD , Hyelim Sung MD , Youngsok Choi PhD , Woo Sik Lee MD, PhD

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Abstract

Objectives

This study investigated the potential of the slow-developing blastocysts using preimplantation genetic testing-aneuploidy (PGT-A) in patients undergoing frozen–thawed embryo transfer, stratified by age.

Methods

A retrospective analysis was performed including a total of 743 cycles, the first frozen embryo transfer (FET) cycle with single embryo transfer, who underwent treatment between January 2020 and July 2023 in a single fertility centre, Gangnam CHA Fertility Center. A total of 743 cycles, in which we performed intracellular sperm injection and freeze-all strategy, from 743 patients were included. The patient group was divided into 4 groups as follows: group 1 (G1), 208 FET on day 5; group 2 (G2), 177 FET with PGT-A on day 5; group 3 (G3), 220 FET on day 6; group 4 (G4), 138 FET with PGT-A on day 6. We also divided into 2 groups—under 35 years of age and over 35 years of age—and performed the analysis separately for each group.

Results

In the under 35 years of age group, there were no significant differences in clinical pregnancy and miscarriage rates in G1 and G2 (67.2% vs. 63.8%, not statistically significantly different). Also, G4 had a higher clinical pregnancy rate than G3, but it was not significant (51.8% vs. 54.7%, not statistically significantly different). In the 35 years or older group, G2 had higher pregnancy rates than G1 and lower miscarriage rates (clinical pregnancy rate: 43.3% vs. 67.7%, P = 0.001, miscarriage rate: 22.5% vs. 3.4%, P = 0.001). In addition, G4 had a higher pregnancy rate than G3 and a lower miscarriage rate (clinical pregnancy rate: 31.8% vs. 46.9%, P = 0.003, miscarriage rate: 22.9% vs. 2.2%, P = 0.023).

Conclusions

In the under-35-year-old group, PGT-A on day 5 and day 6 showed a high pregnancy rate and a low miscarriage rate. Therefore, using PGT-A seems advantageous for patients of an advanced maternal age.

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冷冻解冻周期第 6 天植入前遗传学检测-非整倍体与未植入前遗传学检测-发育缓慢的囊胚临床结果的比较。

研究目的本研究采用植入前遗传学检测-非整倍体（PGT-A）对接受冻融胚胎移植的患者中发育缓慢的囊胚的潜力进行了调查，并按年龄进行了分层：研究进行了一项回顾性分析，共纳入了 743 例在 2020 年 1 月至 2023 年 7 月期间在 XXXX 生育中心接受治疗的首次冷冻胚胎移植（FET）周期的单胚胎移植（SET）患者。我们共纳入了 743 例患者的 743 个周期，在这些周期中，我们进行了细胞内精子注射并冻结了所有策略。患者分为以下 4 组：第 1 组（G1），第 5 天进行 208 次 FET；第 2 组（G2），第 5 天进行 177 次 FET 并使用 PGT-A；第 3 组（G3），第 6 天进行 220 次 FET；第 4 组（G4），第 6 天进行 138 次 FET 并使用 PGT-A。我们还将患者分为两组--35 岁以下组和 35 岁以上组，并对每组分别进行了分析：在 35 岁以下组中，G1 和 G2 的临床妊娠率和流产率无明显差异（67.2% vs 63.8%，NS）。此外，G4 的临床妊娠率高于 G3，但差异不显著（51.8% vs 54.7%，NS）。在 35 岁或以上组中，G2 的妊娠率高于 G1，流产率较低（CPR：43.3% vs 67.7%，P = 0.001；MR：22.5% vs 3.4%，P = 0.001）。此外，G4 的妊娠率高于 G3，流产率较低（CPR：31.8% vs. 46.9%，P = 0.003；MR：22.9% vs. 2.2%，P = 0.023）：在年龄≥35 岁组中，第 5 天和第 6 天的 PGT-A 显示了较高的妊娠率和较低的流产率。因此，使用 PGT-A 似乎对高龄产妇有利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of obstetrics and gynaecology Canada OBSTETRICS & GYNECOLOGY-

CiteScore

3.30

自引率

5.60%

发文量

302

审稿时长

32 days

期刊介绍： Journal of Obstetrics and Gynaecology Canada (JOGC) is Canada"s peer-reviewed journal of obstetrics, gynaecology, and women"s health. Each monthly issue contains original research articles, reviews, case reports, commentaries, and editorials on all aspects of reproductive health. JOGC is the original publication source of evidence-based clinical guidelines, committee opinions, and policy statements that derive from standing or ad hoc committees of the Society of Obstetricians and Gynaecologists of Canada. JOGC is included in the National Library of Medicine"s MEDLINE database, and abstracts from JOGC are accessible on PubMed.