Epigenetic regulation in ovarian cancer.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Hue Vu Thi, Anh-Dao Ngo, Dinh-Toi Chu
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引用次数: 0

Abstract

Ovarian cancer is one of the diseases that have the highest mortality rate for women, especially women over 50 years old. In the future, incidence and mortality rates are predicted to extend in countries with low HDI. Instability in the structure and function of genetic factors has long been known as a cause of cancer, including ovarian cancer. Besides understanding gene mutations, epigenetic alterations have emerged as another aspect leading to the pathogenesis of ovarian neoplasm. The development and progression of this fatal disease have been found to be associated with abnormalities of epigenetic regulation. DNA methylation, histone modification, and non-coding RNAs-based gene silencing are processes of interest in developing ovarian carcinoma and are also new targets for cancer detection or treatment.

卵巢癌的表观遗传调控
卵巢癌是妇女死亡率最高的疾病之一,尤其是 50 岁以上的妇女。据预测,未来人类发展指数较低的国家的发病率和死亡率都将上升。遗传因子结构和功能的不稳定性早已被认为是包括卵巢癌在内的癌症病因。除了了解基因突变外,表观遗传学改变已成为卵巢肿瘤发病机制的另一个方面。研究发现,这种致命疾病的发生和发展与表观遗传调控异常有关。DNA 甲基化、组蛋白修饰和基于非编码 RNA 的基因沉默是卵巢癌发病的重要过程,也是癌症检测或治疗的新靶点。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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