Epigenetic orchestration of the DNA damage response: Insights into the regulatory mechanisms.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Atanu Mondal, Agniswar Sarkar, Dipanwita Das, Amrita Sengupta, Aindrila Kabiraj, Payel Mondal, Rachayita Nag, Shravanti Mukherjee, Chandrima Das
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引用次数: 0

Abstract

The DNA damage response (DDR) is a critical cellular mechanism that safeguards genome integrity and prevents the accumulation of harmful DNA lesions. Increasing evidence highlights the intersection between DDR signaling and epigenetic regulation, offering profound insights into various aspects of cellular function including oncogenesis. This comprehensive review explores the intricate relationship between the epigenetic modifications and DDR activation, with a specific focus on the impact of viral infections. Oncogenic viruses, such as human papillomavirus, hepatitis virus (HBV or HCV), and Epstein-Barr virus have been shown to activate the DDR. Consequently, these DNA damage events trigger a cascade of epigenetic alterations, including changes in DNA methylation patterns, histone modifications and the expression of noncoding RNAs. These epigenetic changes exert profound effects on chromatin structure, gene expression, and maintenance of genome stability. Importantly, elucidation of the viral-induced epigenetic alterations in the context of DDR holds significant implications for comprehending the complexity of cancer and provides potential targets for therapeutic interventions.

DNA 损伤反应的表观遗传协调:洞察调控机制
DNA 损伤应答(DDR)是一种关键的细胞机制,可保护基因组的完整性并防止有害 DNA 病变的积累。越来越多的证据凸显了 DDR 信号传导与表观遗传调控之间的交叉,为包括肿瘤发生在内的细胞功能的各个方面提供了深刻的见解。这篇综合性综述探讨了表观遗传修饰与 DDR 激活之间错综复杂的关系,并特别关注病毒感染的影响。人类乳头瘤病毒、肝炎病毒(HBV 或 HCV)和 Epstein-Barr 病毒等致癌病毒已被证明能激活 DDR。因此,这些 DNA 损伤事件引发了一连串的表观遗传学改变,包括 DNA 甲基化模式、组蛋白修饰和非编码 RNA 表达的改变。这些表观遗传变化对染色质结构、基因表达和基因组稳定性的维持产生了深远影响。重要的是,阐明 DDR 背景下病毒诱导的表观遗传学改变对理解癌症的复杂性具有重要意义,并为治疗干预提供了潜在靶点。
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来源期刊
International review of cell and molecular biology
International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY
CiteScore
7.70
自引率
0.00%
发文量
67
审稿时长
>12 weeks
期刊介绍: International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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