Gastrointestinal Angiectasia in patients with chronic kidney disease: A matched case-control study

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2024-08-22 DOI:10.1016/j.clinre.2024.102454

Sarah Azancot , Xavier Dray , Parastou Moshiri , Adil Soualy , Antoine Guilloux , Pierre Antoine Michel , Jean Jacques Boffa , Aymeric Becq

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引用次数: 0

Abstract

Background and study aims

Chronic kidney disease (CKD) is a well-known risk factor of gastrointestinal angiectasia (GIA). The aim was to compare this population with CDK patients without GIA.

Methods

Patients followed in the Nephrology Department of Tenon Hospital for which an endoscopy was performed between 2012 and 2022 were identified. Those with at least one GIA lesion were included ("GIA+" group). A matched control group for age, sex and GFR stage of patients with CKD and no GIA lesion ("GIA-" group) was constituted. A subgroup analysis compared patients with (SB+) and without (SB-) small-bowel involvement.

Results

A total of 55 patients were included in the GIA+ group. 36.3 % (n = 20) were active smokers and 29.1 % (n = 16) had peripheral arterial disease versus 16.4 % (n = 9) (OR 2.89, p = 0.03), and 9.1 % (n = 5) (OR 4.05, p = 0.015) in the GIA- group. Thirteen patients (23.6 %) had a SB lesion. Duodenal involvement was present in 69.2 % of cases in the SB+ group versus 28.6 % in the SB- group (p = 0.02). Median number of endoscopies, hemostatic technics and hospitalizations was 7, 3 and 6, versus 2 (p = 0.0001), 1 (p = 0.001) and 1 (p = 0.0002) in the SB- group.

Conclusions

CKD patients with GIA had a greater cardiovascular risk with a higher incidence of vascular nephropathy. Small-bowel GIA were associated with a higher morbidity.

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慢性肾病患者的胃肠道血管瘤：一项匹配病例对照研究

背景和研究目的：慢性肾脏病（CKD）是众所周知的胃肠道血管扩张症（GIA）的危险因素。研究的目的是将这一人群与无 GIA 的 CDK 患者进行比较：方法：筛选出 2012 年至 2022 年期间在特农医院肾内科接受过内镜检查的患者。其中包括至少有一处 GIA 病变的患者（"GIA+"组）。在年龄、性别和肾小球滤过率分期上与患有慢性肾功能衰竭且无 GIA 病变的患者组成匹配对照组（"GIA-"组）。对有小肠受累（SB+）和无小肠受累（SB-）的患者进行了亚组分析比较：结果：共有 55 名患者被纳入 GIA+ 组。GIA+组中有36.3%（n=20）的患者为主动吸烟者，29.1%（n=16）的患者患有外周动脉疾病，而GIA-组中有16.4%（n=9）（OR 2.89，p=0.03）和9.1%（n=5）（OR 4.05，p=0.015）的患者患有外周动脉疾病。13名患者（23.6%）有SB病变。SB+组有69.2%的病例出现十二指肠受累，而SB-组仅有28.6%（P=0.02）。内镜检查、止血技术和住院次数的中位数分别为 7 次、3 次和 6 次，而 SB- 组分别为 2 次（P=0.0001）、1 次（P=0.001）和 1 次（P=0.0002）：结论：患有 GIA 的慢性肾脏病患者心血管风险更大，血管性肾病的发病率更高。小肠GIA与较高的发病率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.