Clinical efficacy of 595 nm pulsed dye laser in combination with supramolecular salicylic acid in the treatment of rosacea.

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2024-08-24 DOI:10.1007/s00403-024-03290-9

Wei Lei, Huang Chen, Liuqing Chen, Meng Li, Jun Zhang, Xuegang Xu

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引用次数: 0

Abstract

Objective: This research was aimed at ascertaining the clinical effects of 595 nm pulsed dye laser (PDL) in combination with supramolecular salicylic acid (SSA) in the treatment of rosacea.

Methods: Eighty-four patients with rosacea were selected, of which 42 patients treated with PDL alone were considered as the control group, and 42 patients treated with 595 nm PDL in combination with 30% SSA were regarded as the observation group. The treatment continued for 4 months in the two groups. Clinical symptom scores, skin barrier function indicators, serum inflammatory factors, Acne⁃QOL scores and adverse reactions between the two groups were compared.

Results: After treatment, levels of inflammatory factors, clinical symptom scores, transdermal water loss, and oil volume were decreased, and epidermal water content and Acne-QOL scores were increased in both groups (all P < 0.05), and the changes in the observation group were more pronounced versus the control group (all P < 0.05). The difference in the incidence of adverse reactions was not statistically significant between the two groups (P > 0.05).

Conclusion: 595 nm PDL in combination with SSA is safe in the treatment of rosacea.

查看原文本刊更多论文

595 nm 脉冲染料激光联合超分子水杨酸治疗红斑痤疮的临床疗效。

研究目的本研究旨在确定 595 nm 脉冲染料激光（PDL）联合超分子水杨酸（SSA）治疗酒渣鼻的临床效果：选取84例酒糟鼻患者，其中42例单用PDL治疗者为对照组，42例595 nm PDL联合30%SSA治疗者为观察组。两组患者的治疗均持续 4 个月。比较两组患者的临床症状评分、皮肤屏障功能指标、血清炎症因子、Acne⁃QOL评分及不良反应：结果：治疗后，两组炎症因子水平、临床症状评分、透皮失水、油脂量均下降，表皮含水量、Acne⁃QOL评分均上升（均P 0.05）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.