Synthetic Nicotinamide Cofactors as Alternatives to NADPH in Imine Reductase-Catalyzed Reactions

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-08-23 DOI:10.1021/acs.orglett.4c02560

Wei Kang, Shushan Gao, Jinping Bao, Lujia Yang, Yaqing Ma, Pingyuan Wang, Chang-Yun Wang, Chengsen Cui

引用次数: 0

Abstract

This study demonstrates the effectiveness of synthetic nicotinamide cofactors as cost-effective alternatives to NADPH in imine reductase (IRED) catalysis. The synthetic cofactors maintained catalytic activity and stereoselectivity, achieving high conversion rates. Molecular docking studies revealed key structural interactions influencing performance. Combining a glucose dehydrogenase (GDH) recycling system further enhanced the stability and efficiency. These findings highlight the potential of synthetic cofactors to reduce costs and improve the feasibility of IRED-catalyzed processes for industrial applications.

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在亚胺还原酶催化反应中替代 NADPH 的合成烟酰胺辅助因子

本研究证明了合成烟酰胺辅助因子在亚胺还原酶（IRED）催化过程中作为 NADPH 的经济有效替代品的有效性。合成的辅助因子保持了催化活性和立体选择性，实现了高转化率。分子对接研究揭示了影响性能的关键结构相互作用。结合葡萄糖脱氢酶 (GDH) 循环系统进一步提高了稳定性和效率。这些发现凸显了合成辅助因子在降低成本和提高工业应用 IRED 催化过程的可行性方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.