Xiaohua Liu, Yike Guo, Jiangpeng Pan, Tingting Wu, Bing Zhao, Shuyi Wei, Wei Jiang and Ying Liu
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引用次数: 0
Abstract
Acute kidney injury (AKI) is a severe clinical syndrome characterized by rapid deterioration of renal function caused by a variety of pathogeneses. Natural polyphenols have been considered to have potential in the treatment of AKI due to their powerful antioxidant and anti-inflammatory activities, but their low bioavailability in vivo limits their efficacy. Polyphenol nanoparticles based on a nano-delivery system show good effects in reducing kidney injury, improving renal function and promoting renal tissue repair, and brings new hope and possibility for the treatment of AKI. This review provides an overview of the common characteristics, treatments, and associated adverse effects of AKI. The classification and bioavailability of polyphenols as well as their therapeutic role in AKI and potential possible effects are outlined. The potential therapeutic effects of polyphenol-based nanoparticles on AKI and the underlying mechanisms are discussed.
急性肾损伤(AKI)是一种严重的临床综合征,其特点是由多种病原体引起的肾功能迅速恶化。天然多酚具有强大的抗氧化和抗炎活性,因此被认为具有治疗急性肾损伤的潜力,但它们在体内的低生物利用度限制了其疗效。基于纳米给药系统的多酚纳米颗粒在减轻肾损伤、改善肾功能和促进肾组织修复方面显示出良好的效果,为治疗 AKI 带来了新的希望和可能。本综述概述了 AKI 的常见特点、治疗方法和相关不良反应。概述了多酚类物质的分类和生物利用度,以及它们在 AKI 中的治疗作用和可能产生的潜在影响。还讨论了基于多酚的纳米颗粒对 AKI 的潜在治疗效果及其内在机制。
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices