A systematic review of spirostanol saponins and anticancer natural products isolated from Tacca plantaginea (Hance) Drenth

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-08-22 DOI:10.1016/j.phytochem.2024.114252

{"title":"A systematic review of spirostanol saponins and anticancer natural products isolated from Tacca plantaginea (Hance) Drenth","authors":"","doi":"10.1016/j.phytochem.2024.114252","DOIUrl":null,"url":null,"abstract":"<div>The plant genus Tacca comprises twenty species including Tacca plantaginea, essentially distributed in the Indo-China region. Medicinal preparations from the rhizomes are used traditionally to treat gastrointestinal ailments, stomach aches and inflammatory disorders. A variety of bioactive molecules have been isolated from T. plantaginea, including potent anticancer steroids such as the taccanolides which interfere with microtubules dynamic. Other efficient anticancer natural products have been isolated from the plant, in particular a series of diosgenin/yamogenin-type sapogenins including taccaoside (monodesmosidic) and taccaoside A (bidesmosidic). Taccaoside A displays marked anticancer properties through two complementary mechanisms: a direct action on cancer stem cells via HRas and Pi3K/Akt signaling and an indirect immunomodulatory action via activation of cytotoxic T cells. A similar mechanism of action has been invoked with a total saponin extract from Schizocapsa plantaginea Hance (synonym to T. plantaginea) and the saponin SSPH 1. This saponin reduced tumor growth in mice through stimulation of cytotoxic T lymphocytes. Other bioactive products have been isolated from T. plantaginea, including withanolide-type steroids (plantagiolides, chantriolides), diarylheptanoids (plantagineosides) and different saponins (diosbulbisides, lieguonins). The discussion centers around the mechanism of action of spirostanol saponins, with the objective to promote their study as immuno-active anticancer agents.</div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002899","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The plant genus Tacca comprises twenty species including Tacca plantaginea, essentially distributed in the Indo-China region. Medicinal preparations from the rhizomes are used traditionally to treat gastrointestinal ailments, stomach aches and inflammatory disorders. A variety of bioactive molecules have been isolated from T. plantaginea, including potent anticancer steroids such as the taccanolides which interfere with microtubules dynamic. Other efficient anticancer natural products have been isolated from the plant, in particular a series of diosgenin/yamogenin-type sapogenins including taccaoside (monodesmosidic) and taccaoside A (bidesmosidic). Taccaoside A displays marked anticancer properties through two complementary mechanisms: a direct action on cancer stem cells via HRas and Pi3K/Akt signaling and an indirect immunomodulatory action via activation of cytotoxic T cells. A similar mechanism of action has been invoked with a total saponin extract from Schizocapsa plantaginea Hance (synonym to T. plantaginea) and the saponin SSPH 1. This saponin reduced tumor growth in mice through stimulation of cytotoxic T lymphocytes. Other bioactive products have been isolated from T. plantaginea, including withanolide-type steroids (plantagiolides, chantriolides), diarylheptanoids (plantagineosides) and different saponins (diosbulbisides, lieguonins). The discussion centers around the mechanism of action of spirostanol saponins, with the objective to promote their study as immuno-active anticancer agents.

Abstract Image

查看原文本刊更多论文

从 Tacca plantaginea (Hance) Drenth 中分离的螺甾醇皂甙和抗癌天然产物的系统综述。

Tacca 属植物包括 Tacca plantaginea 在内的 20 个物种，主要分布在印度支那地区。从根茎中提取的药剂传统上用于治疗肠胃疾病、胃痛和炎症。已从车前草中分离出多种生物活性分子，包括强效抗癌类固醇，如干扰微管动态的 Taccanolides。从该植物中还分离出了其他高效抗癌天然产物，特别是一系列薯蓣皂苷元/薯蓣皂苷元类型的苷元，包括他卡西苷（单苷元）和他卡西苷 A（双苷元）。漆树苷 A 通过两种互补机制显示出明显的抗癌特性：通过 HRas 和 Pi3K/Akt 信号转导直接作用于癌症干细胞，以及通过激活细胞毒性 T 细胞间接发挥免疫调节作用。Schizocapsa plantaginea Hance（T. plantaginea 的异名）的总皂苷提取物和皂苷 SSPH 1 也具有类似的作用机制。这种皂苷通过刺激细胞毒性 T 淋巴细胞来减少小鼠的肿瘤生长。从车前草中还分离出了其他具有生物活性的产品，包括内酯类固醇（车前草内酯、车前草醇内酯）、二芳基庚酸类（车前草苷）和不同的皂苷（车前草双苷、车前草皂苷）。讨论围绕螺甾醇皂苷的作用机制展开，目的是促进对其作为免疫活性抗癌剂的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.