Clinical significance of serum soluble scavenger receptor CD163 in patients with lupus nephritis.

IF 1.9 4区医学 Q3 RHEUMATOLOGY

Lupus Pub Date : 2024-08-22 DOI:10.1177/09612033241276033

Yanjie Liu, Meiyan Li, Huamei Zhang, Zhe Yin, Xiaoli Wang

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Abstract

Background: The soluble CD163 (sCD163) was elevated in systemic lupus erythematosus (SLE) patients.

Purpose: To study whether serum sCD163 could be used to predict the occurrence and prognosis of lupus nephritis (LN).

Research design: The recruited patients were classified into different groups according to standard identification criteria.

Study sample: The patients with LN.

Data collection and analysis: 11 indices were analyzed and compared in SLE and LN patients. Furthermore, the level of serum sCD163 was detected using an enzyme-linked immunosorbent assay. Meanwhile, the receiver operating characteristic analysis was performed to evaluate the prediction effect of sCD163. Additionally, spearman correlation analysis of serum sCD163 with indices was conducted.

Results: There were six positive indices and one negative risk factor correlated to LN. sCD163 was elevated in LN patients and could be used to diagnose LN. Importantly, sCD163 was increased in LN patients with a heavy SLE disease activity index. Finally, it was revealed that the level of sCD163 was higher in the LN patients with no response than that with complete or partial response, which also could predict the prognosis of LN.

Conclusions: Serum sCD163 was elevated in LN patients than in SLE patients, which could be used to predict the occurrence and prognosis of LN.

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狼疮性肾炎患者血清中可溶性清道夫受体 CD163 的临床意义。

背景：可溶性CD163（sCD163）在系统性红斑狼疮（SLE）患者中升高：目的：研究血清可溶性CD163（sCD163）是否可用于预测狼疮性肾炎（LN）的发生和预后：研究样本：LN患者：数据收集和分析：对系统性红斑狼疮和狼疮性肾炎患者的 11 项指标进行分析和比较。此外，还使用酶联免疫吸附试验检测了血清中 sCD163 的水平。同时，对 sCD163 的预测效果进行了接收者操作特征分析。此外，还对血清 sCD163 与指数进行了 spearman 相关性分析：结果：有六项阳性指标和一项阴性危险因素与 LN 相关。LN 患者的 sCD163 升高，可用于诊断 LN。重要的是，sCD163 在系统性红斑狼疮疾病活动指数较高的 LN 患者中升高。最后，研究发现，无应答的LN患者的sCD163水平高于完全或部分应答的患者，这也可以预测LN的预后：结论：与系统性红斑狼疮患者相比，LN 患者的血清 sCD163 水平升高，可用于预测 LN 的发生和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lupus 医学-风湿病学

CiteScore

4.20

自引率

11.50%

发文量

225

审稿时长

1 months

期刊介绍： The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…

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