WITHDRAWN: Comparative Experimental Study of using Tramadol and Nefopam in Pain Management

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Combinatorial chemistry & high throughput screening Pub Date : 2024-08-22 DOI:10.2174/0113862073252534231122073045

Gaber El-Saber Batiha, Hayder M Al-Kuraishy, Omnia Momtaz Al-Fakhrany, Engy Elekhnawy

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引用次数: 0

Abstract

The manuscript has been withdrawn upon author request.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Additionally, plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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使用曲马多和奈福泮治疗疼痛的对比实验研究

背景：疼痛是一种令人不安的感觉和情绪，主要由组织损伤性刺激引发。本研究旨在评估曲马多和奈福泮对急性疼痛的潜在影响：将 30 只 Sprague-Dawley 大鼠（每只 200-250 克）随机分为三组（n=10）。奈福泮组腹腔注射奈福泮（3.5 毫克/千克），曲马多组腹腔注射曲马多（50 毫克/千克），对照组用生理盐水。评估和监测大鼠疼痛的方法主要有两种：热板法和浸入尾部的弹尾法：结果表明：与对照组相比，接受曲马多和奈福泮治疗的动物疼痛有明显变化（P0.05）。此外，热板试验（手爪舔参数）和尾晕试验在曲马多治疗组和奈福泮治疗组之间也发现了相当大的差异。然而，在热板试验（跳跃参数）中，两组之间未发现明显差异（P=0.101）：结论：在中度至重度疼痛的急性期，曲马多在抑制疼痛刺激方面的镇痛活性优于奈福泮，因此曲马多是短期治疗术后疼痛的首选。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Combinatorial chemistry & high throughput screening 化学-生化研究方法

CiteScore

3.10

自引率

5.60%

发文量

327

审稿时长

7.5 months

期刊介绍： Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. Original research articles and reviews in the following areas are of special interest to the readers of this journal: Target identification and validation Assay design, development, miniaturization and comparison High throughput/high content/in silico screening and associated technologies Label-free detection technologies and applications Stem cell technologies Biomarkers ADMET/PK/PD methodologies and screening Probe discovery and development, hit to lead optimization Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) Chemical library design and chemical diversity Chemo/bio-informatics, data mining Compound management Pharmacognosy Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) Natural Product Analytical Studies Bipharmaceutical studies of Natural products Drug repurposing Data management and statistical analysis Laboratory automation, robotics, microfluidics, signal detection technologies Current & Future Institutional Research Profile Technology transfer, legal and licensing issues Patents.