Does Mild Functional Impairment Predict Dementia in Older Adults With Normal Cognition?

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI:10.1097/WAD.0000000000000638

Lei Lei Zhang, Katya Numbers, Henry Brodaty, Ben C P Lam, Gowsaly Mahalingam, Simone Reppermund

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引用次数: 0

Abstract

Objectives: Functional impairment can be an early indicator of cognitive decline. However, its predictive utility in cognitively normal (CN) older adults remains unclear. This study aimed to determine whether mild functional impairment (MFI) in CN older adults could predict incident dementia over 6 years, in addition to assessing its association with cognitive performance.

Design: A longitudinal study with a 6-year follow-up.

Participants: A cohort of 296 community-dwelling CN older adults.

Measurements: MFI was defined by cutoffs for impairment on an objective performance-based and/or subjective questionnaire-based functional assessment. Cox regression analysis was conducted to assess the relationship between MFI and risk of incident dementia and cognitive performances over 6 years. Linear regression analysis examined the association between MFI and baseline cognitive performance.

Results: There were no significant longitudinal associations between MFI and incident dementia or changes in cognitive performance over 6 years. Defining MFI using both performance-based and informant-reported assessments was predictive of dementia. Cross-sectional analyses demonstrated significant associations between MFI and poorer baseline global cognition and performance in attention, visuospatial ability, and executive functioning.

Conclusions: CN older adults with MFI were not at an increased risk of developing dementia over 6 years. A definition of functional impairment requiring both performance-based and informant-based assessments may be useful in predicting dementia.

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轻度功能障碍能预测认知正常的老年人患痴呆症吗？

目的：功能障碍是认知能力下降的早期指标。然而，其对认知正常（CN）老年人的预测作用仍不明确。本研究旨在确定认知正常老年人的轻度功能障碍（MFI）是否能预测6年内痴呆症的发生，同时评估其与认知表现的关系：设计：一项为期 6 年的纵向研究：296名居住在社区的中老年人：MFI根据基于客观表现的功能评估和/或基于主观问卷的功能评估的损伤临界值进行定义。进行了 Cox 回归分析，以评估 MFI 与 6 年内痴呆症发病风险和认知能力之间的关系。线性回归分析检验了MFI与基线认知表现之间的关系：结果：6年间，MFI与痴呆症发病风险或认知能力变化之间没有明显的纵向联系。使用基于表现的评估和线人报告的评估来定义MFI可预测痴呆症。横断面分析表明，MFI 与较差的基线总体认知能力以及注意力、视觉空间能力和执行功能表现之间存在显著关联：结论：患有功能障碍的中老年人在 6 年内罹患痴呆症的风险并没有增加。功能障碍的定义需要同时进行基于表现的评估和基于信息的评估，这可能有助于预测痴呆症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.