Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2024-08-22 eCollection Date: 2024-08-01 DOI:10.14309/crj.0000000000001467

Wei Tang, Zilan Lin, Pritika Sharma, Gabriel Heering, Brad Dworkin, Amir Steinberg, Fouzia Shakil, Beth Schorr-Lesnick

引用次数: 0

Abstract

Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.

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胃肠道α-重链疾病伴有持续的空肠弯曲菌定植和难治性贾第虫病。

α重链病（αHCD）是粘膜相关淋巴组织淋巴瘤的一种罕见变异型，其特点是表达单型截短的免疫球蛋白α重链。αHCD经常累及胃肠道，其发病机制与感染性病原体的慢性免疫刺激导致的B细胞克隆性扩增有关。我们报告了一例罕见的胃肠道αHCD病例，该病例在胃肠道多重实时聚合酶链反应面板上发现了5种并发病原体，其特点是空肠弯曲菌持续定植和难治性胃肠炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.